Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children
Objectives Provitamin A carotenoid biofortified “orange” maize has been developed as a vitamin A deficiency control strategy using selective breeding for the β-carotene hydroxylase-1 gene, which increases β-carotene, β-cryptoxanthin, and zeaxanthin in the endosperm. We conducted a cluster-randomized...
| Main Authors: | , , , , , , , |
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| Format: | Abstract |
| Language: | Inglés |
| Published: |
Wiley
2017
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| Online Access: | https://hdl.handle.net/10568/171052 |
| _version_ | 1855527888398319616 |
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| author | Craft, Neal E. Palmer, Amanda Schultze, Kerry Chileshe, Justin Barffour, Maxwell Siamusantu, Ward Klemm, Rolf West, Keith |
| author_browse | Barffour, Maxwell Chileshe, Justin Craft, Neal E. Klemm, Rolf Palmer, Amanda Schultze, Kerry Siamusantu, Ward West, Keith |
| author_facet | Craft, Neal E. Palmer, Amanda Schultze, Kerry Chileshe, Justin Barffour, Maxwell Siamusantu, Ward Klemm, Rolf West, Keith |
| author_sort | Craft, Neal E. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Objectives Provitamin A carotenoid biofortified “orange” maize has been developed as a vitamin A deficiency control strategy using selective breeding for the β-carotene hydroxylase-1 gene, which increases β-carotene, β-cryptoxanthin, and zeaxanthin in the endosperm. We conducted a cluster-randomized trial to test the impact of orange maize consumption (a predominantly β-carotene-rich variety) on serum retinol concentration in rural Zambian children (4–8 y). In the present analysis, we tested the intervention’s impact on circulating carotenoids. Methods Children (n=1024, 4–8 y) were cluster-randomized to receive 200 g dry weight/d orange or conventional “white” maize prepared with standardized low-vitamin A relishes, 6 d/w for 6 m. The carotenoid profile was assessed in baseline and follow-up serum samples in a subset (n=321 white, n=358 orange) of children. We assessed differences in log-transformed carotenoids, expressed as geometric means and 95% confidence limits, accounting for cluster randomization. Results Baseline carotenoids did not differ between groups. There were no differences in lycopene and lutein between groups at follow-up. Other carotenoids increased significantly (p<0.001) in orange vs white groups following the six-month intervention: β-carotene [273 (254,292) vs 147 (135,160) nmol/L], α-carotene [19.7 (18.4,21.1) vs 10.6 (9.9,11.3) nmol/L], β-cryptoxanthin [36.1 (33.6,38.8) vs 12.6 (11.8,13.5) nmol/L], α-cryptoxanthin [18.7 (17.4,20.1) vs 8.9 (8.4,9.4) nmol/L], zeaxanthin [127 (119,135) vs 81 (75,88) nmol/L]. Conclusions Children regularly consuming a biofortified maize variety bred primarily for β-carotene had higher concentrations of other provitamin A carotenoids and zeaxanthin, suggesting the potential for health benefits beyond vitamin A deficiency control. |
| format | Abstract |
| id | CGSpace171052 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace1710522025-02-19T14:31:11Z Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children Craft, Neal E. Palmer, Amanda Schultze, Kerry Chileshe, Justin Barffour, Maxwell Siamusantu, Ward Klemm, Rolf West, Keith provitamins metabolism retinol maize food production carotenes children nutrition Objectives Provitamin A carotenoid biofortified “orange” maize has been developed as a vitamin A deficiency control strategy using selective breeding for the β-carotene hydroxylase-1 gene, which increases β-carotene, β-cryptoxanthin, and zeaxanthin in the endosperm. We conducted a cluster-randomized trial to test the impact of orange maize consumption (a predominantly β-carotene-rich variety) on serum retinol concentration in rural Zambian children (4–8 y). In the present analysis, we tested the intervention’s impact on circulating carotenoids. Methods Children (n=1024, 4–8 y) were cluster-randomized to receive 200 g dry weight/d orange or conventional “white” maize prepared with standardized low-vitamin A relishes, 6 d/w for 6 m. The carotenoid profile was assessed in baseline and follow-up serum samples in a subset (n=321 white, n=358 orange) of children. We assessed differences in log-transformed carotenoids, expressed as geometric means and 95% confidence limits, accounting for cluster randomization. Results Baseline carotenoids did not differ between groups. There were no differences in lycopene and lutein between groups at follow-up. Other carotenoids increased significantly (p<0.001) in orange vs white groups following the six-month intervention: β-carotene [273 (254,292) vs 147 (135,160) nmol/L], α-carotene [19.7 (18.4,21.1) vs 10.6 (9.9,11.3) nmol/L], β-cryptoxanthin [36.1 (33.6,38.8) vs 12.6 (11.8,13.5) nmol/L], α-cryptoxanthin [18.7 (17.4,20.1) vs 8.9 (8.4,9.4) nmol/L], zeaxanthin [127 (119,135) vs 81 (75,88) nmol/L]. Conclusions Children regularly consuming a biofortified maize variety bred primarily for β-carotene had higher concentrations of other provitamin A carotenoids and zeaxanthin, suggesting the potential for health benefits beyond vitamin A deficiency control. 2017-04 2025-01-29T12:57:39Z 2025-01-29T12:57:39Z Abstract https://hdl.handle.net/10568/171052 en Limited Access Wiley Craft, Neal E.; Palmer, Amanda; Schultze, Kerry; Chileshe, Justin; Barffour, Maxwell; Siamusantu, Ward; Klemm, Rolf; and West, Keith. 2017. Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children. FASEB Journal 31 (1): Supplement 786.17: https://doi.org/10.1096/fasebj.31.1_supplement.786.17 |
| spellingShingle | provitamins metabolism retinol maize food production carotenes children nutrition Craft, Neal E. Palmer, Amanda Schultze, Kerry Chileshe, Justin Barffour, Maxwell Siamusantu, Ward Klemm, Rolf West, Keith Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children |
| title | Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children |
| title_full | Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children |
| title_fullStr | Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children |
| title_full_unstemmed | Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children |
| title_short | Impact of provitamin A biofortified maize consumption on carotenoid status of Zambian children |
| title_sort | impact of provitamin a biofortified maize consumption on carotenoid status of zambian children |
| topic | provitamins metabolism retinol maize food production carotenes children nutrition |
| url | https://hdl.handle.net/10568/171052 |
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