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Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems

Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers pro...

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Main Authors: Fernández, Luciana, Reviglio, Ana Lucía, Heredia, Daniel A., Morales, Gustavo M., Santo, Marisa, Otero, Luis, Alustiza, Fabrisio Eduardo, Liaudat, Ana Cecilia, Bosch, Pablo, Larghi, Enrique L., Bracca, Andrea B.J., Kaufman, Teodoro S.
Format: Artículo
Language:Inglés
Published: Elsevier 2021
Subjects:
Cultivo de Células
Compuestos Bioactivos
Sistemas de Administración de Drogas
Transportadores de Fármacos
Cell Culture
Bioactive Compounds
Drug Delivery Systems
Drug Carriers
Online Access:http://hdl.handle.net/20.500.12123/8902
https://www.sciencedirect.com/science/article/pii/S2405844021005417
https://doi.org/10.1016/j.heliyon.2021.e06436
Summary:Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures.

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