Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems
Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers pro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Elsevier
2021
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/8902 https://www.sciencedirect.com/science/article/pii/S2405844021005417 https://doi.org/10.1016/j.heliyon.2021.e06436 |
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| author | Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Eduardo Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. |
| author_browse | Alustiza, Fabrisio Eduardo Bosch, Pablo Bracca, Andrea B.J. Fernández, Luciana Heredia, Daniel A. Kaufman, Teodoro S. Larghi, Enrique L. Liaudat, Ana Cecilia Morales, Gustavo M. Otero, Luis Reviglio, Ana Lucía Santo, Marisa |
| author_facet | Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Eduardo Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. |
| author_sort | Fernández, Luciana |
| collection | INTA Digital |
| description | Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures. |
| format | Artículo |
| id | INTA8902 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA89022021-03-16T14:33:54Z Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Eduardo Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. Cultivo de Células Compuestos Bioactivos Sistemas de Administración de Drogas Transportadores de Fármacos Cell Culture Bioactive Compounds Drug Delivery Systems Drug Carriers Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures. EEA Marcos Juárez Fil: Fernández, Luciana. Universidad Nacional de Río Cuarto. Departamento de Física y Departamento de Química; Argentina Fil: Fernández, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Reviglio, Ana Lucía. Universidad Nacional de Río Cuarto. Departamento de Física y Departamento de Química; Argentina Fil: Reviglio, Ana Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Heredia, Daniel A. Universidad Nacional de Río Cuarto. Departamento de Física y Departamento de Química; Argentina. Fil: Heredia, Daniel A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Morales, Gustavo M. Universidad Nacional de Río Cuarto. Departamento de Física y Departamento de Química; Argentina Fil: Morales, Gustavo M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Santo, Marisa. Universidad Nacional de Río Cuarto. Departamento de Física y Departamento de Química; Argentina Fil: Santo, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Otero, Luis. Universidad Nacional de Río Cuarto. Departamento de Física y Departamento de Química; Argentina Fil: Otero, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Alustiza, Fabrisio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Departamento de Biología Molecular; Argentina Fil: Bosch, Pablo. Universidad Nacional de Río Cuarto. Departamento de Biología Molecular; Argentina Fil: Larghi, Enrique L. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Bracca, Andrea B.J. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Kaufman, Teodoro S. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina 2021-03-16T14:29:10Z 2021-03-16T14:29:10Z 2021-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/8902 https://www.sciencedirect.com/science/article/pii/S2405844021005417 2405-8440 https://doi.org/10.1016/j.heliyon.2021.e06436 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Heliyon 7 (3) : e06436 (March 2021) |
| spellingShingle | Cultivo de Células Compuestos Bioactivos Sistemas de Administración de Drogas Transportadores de Fármacos Cell Culture Bioactive Compounds Drug Delivery Systems Drug Carriers Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Eduardo Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
| title | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
| title_full | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
| title_fullStr | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
| title_full_unstemmed | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
| title_short | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
| title_sort | langmuir blodgett monolayers holding a wound healing active compound and its effect in cell culture a model for the study of surface mediated drug delivery systems |
| topic | Cultivo de Células Compuestos Bioactivos Sistemas de Administración de Drogas Transportadores de Fármacos Cell Culture Bioactive Compounds Drug Delivery Systems Drug Carriers |
| url | http://hdl.handle.net/20.500.12123/8902 https://www.sciencedirect.com/science/article/pii/S2405844021005417 https://doi.org/10.1016/j.heliyon.2021.e06436 |
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