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Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test

Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation inf...

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Main Authors: Knoppe, T.N., Bauer, B., McDermott, John J., Peregrine, A.S., Mehlitz, D., Clausen, Peter-Henning
Format: Journal Article
Language:Inglés
Published: Elsevier 2006
Subjects:
trypanosoma congolense
drug therapy
mice
cattle
pathogenicity
incubators
infectious diseases
parasitology
Online Access:https://hdl.handle.net/10568/29974
Summary:Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation infectivity test (DIIT). All field stocks from Kenedougou were resistant to 1.0 mg/kg bw isometamidium in the SMT. Fourteen stocks (87.5%) also proved to be refractory to 10 mg/kg bw. Testing with the DIIT confirmed the results of the SMT. By comparison to reference clones, all the Kenedougou populations expressed high levels of resistance to isometamidium.

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