Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test
Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation inf...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2006
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/29974 |
| _version_ | 1855513081230131200 |
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| author | Knoppe, T.N. Bauer, B. McDermott, John J. Peregrine, A.S. Mehlitz, D. Clausen, Peter-Henning |
| author_browse | Bauer, B. Clausen, Peter-Henning Knoppe, T.N. McDermott, John J. Mehlitz, D. Peregrine, A.S. |
| author_facet | Knoppe, T.N. Bauer, B. McDermott, John J. Peregrine, A.S. Mehlitz, D. Clausen, Peter-Henning |
| author_sort | Knoppe, T.N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation infectivity test (DIIT). All field stocks from Kenedougou were resistant to 1.0 mg/kg bw isometamidium in the SMT. Fourteen stocks (87.5%) also proved to be refractory to 10 mg/kg bw. Testing with the DIIT confirmed the results of the SMT. By comparison to reference clones, all the Kenedougou populations expressed high levels of resistance to isometamidium. |
| format | Journal Article |
| id | CGSpace29974 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace299742024-03-06T10:16:43Z Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test Knoppe, T.N. Bauer, B. McDermott, John J. Peregrine, A.S. Mehlitz, D. Clausen, Peter-Henning trypanosoma congolense drug therapy mice cattle pathogenicity incubators infectious diseases parasitology Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation infectivity test (DIIT). All field stocks from Kenedougou were resistant to 1.0 mg/kg bw isometamidium in the SMT. Fourteen stocks (87.5%) also proved to be refractory to 10 mg/kg bw. Testing with the DIIT confirmed the results of the SMT. By comparison to reference clones, all the Kenedougou populations expressed high levels of resistance to isometamidium. 2006-01 2013-06-11T09:25:39Z 2013-06-11T09:25:39Z Journal Article https://hdl.handle.net/10568/29974 en Limited Access Elsevier Acta Tropica;97(1): 108-116 |
| spellingShingle | trypanosoma congolense drug therapy mice cattle pathogenicity incubators infectious diseases parasitology Knoppe, T.N. Bauer, B. McDermott, John J. Peregrine, A.S. Mehlitz, D. Clausen, Peter-Henning Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test |
| title | Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test |
| title_full | Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test |
| title_fullStr | Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test |
| title_full_unstemmed | Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test |
| title_short | Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test |
| title_sort | isometamidium sensitivity of trypanosoma congolense stocks from cattle in west africa tested in mice and the drug incubation infectivity test |
| topic | trypanosoma congolense drug therapy mice cattle pathogenicity incubators infectious diseases parasitology |
| url | https://hdl.handle.net/10568/29974 |
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