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Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells

Iron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an endocytic...

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Main Authors: Perfecto, Antonio, Rodriguez-Ramiro, Ildefonso, Rodriguez-Celma, Jorge, Sharp, Paul, Balk, Janneke, Fairweather-Tait, Susan J.
Format: Journal Article
Language:Inglés
Published: Oxford University Press 2018
Subjects:
iron
cells
stability
peas
pisum sativum
ferritin
mineral supplements
bioavailability
endocytosis
vitamin deficiencies
pea protein
Online Access:https://hdl.handle.net/10568/171196
Summary:Iron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an endocytic mechanism, independent of divalent metal ion transporter 1 (DMT-1), the transporter for nonheme iron.

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