Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells
Iron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an endocytic...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/171196 |
| _version_ | 1855517781597880320 |
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| author | Perfecto, Antonio Rodriguez-Ramiro, Ildefonso Rodriguez-Celma, Jorge Sharp, Paul Balk, Janneke Fairweather-Tait, Susan J. |
| author_browse | Balk, Janneke Fairweather-Tait, Susan J. Perfecto, Antonio Rodriguez-Celma, Jorge Rodriguez-Ramiro, Ildefonso Sharp, Paul |
| author_facet | Perfecto, Antonio Rodriguez-Ramiro, Ildefonso Rodriguez-Celma, Jorge Sharp, Paul Balk, Janneke Fairweather-Tait, Susan J. |
| author_sort | Perfecto, Antonio |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Iron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an endocytic mechanism, independent of divalent metal ion transporter 1 (DMT-1), the transporter for nonheme iron. |
| format | Journal Article |
| id | CGSpace171196 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1711962025-12-08T10:06:44Z Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells Perfecto, Antonio Rodriguez-Ramiro, Ildefonso Rodriguez-Celma, Jorge Sharp, Paul Balk, Janneke Fairweather-Tait, Susan J. iron cells stability peas pisum sativum ferritin mineral supplements bioavailability endocytosis vitamin deficiencies pea protein Iron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an endocytic mechanism, independent of divalent metal ion transporter 1 (DMT-1), the transporter for nonheme iron. 2018-08 2025-01-29T12:57:50Z 2025-01-29T12:57:50Z Journal Article https://hdl.handle.net/10568/171196 en Open Access Oxford University Press Perfecto, Antonio; Rodriguez-Ramiro, Ildefonso; Rodriguez-Celma, Jorge; Sharp, Paul; Balk, Janneke; and Fairweather-Tait, Susan J. 2018. Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in Caco-2 cells. Journal of Nutrition 148(8): 1229-1235. https://doi.org/10.1093/jn/nxy096 |
| spellingShingle | iron cells stability peas pisum sativum ferritin mineral supplements bioavailability endocytosis vitamin deficiencies pea protein Perfecto, Antonio Rodriguez-Ramiro, Ildefonso Rodriguez-Celma, Jorge Sharp, Paul Balk, Janneke Fairweather-Tait, Susan J. Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells |
| title | Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells |
| title_full | Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells |
| title_fullStr | Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells |
| title_full_unstemmed | Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells |
| title_short | Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in caco-2 cells |
| title_sort | pea ferritin stability under gastric ph conditions determines the mechanism of iron uptake in caco 2 cells |
| topic | iron cells stability peas pisum sativum ferritin mineral supplements bioavailability endocytosis vitamin deficiencies pea protein |
| url | https://hdl.handle.net/10568/171196 |
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