Pathogenesis and risk factors of feline infectious peritonitis
Feline infectious peritonitis (FIP) is a fatal disease amongst both domesticated and wild felines. Pathogenesis behind FIP is not completely clear, but the consensus states that Feline coronavirus (FCoV) acquires mutations in genes that code for example the Spike (S) protein and 3c (Bank-Wolf et al....
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| Formato: | First cycle, G2E |
| Lenguaje: | sueco Inglés |
| Publicado: |
2019
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| Acceso en línea: | https://stud.epsilon.slu.se/14405/ |
| _version_ | 1855572401894457344 |
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| author | Arkela, Kristian |
| author_browse | Arkela, Kristian |
| author_facet | Arkela, Kristian |
| author_sort | Arkela, Kristian |
| collection | Epsilon Archive for Student Projects |
| description | Feline infectious peritonitis (FIP) is a fatal disease amongst both domesticated and wild felines. Pathogenesis behind FIP is not completely clear, but the consensus states that Feline coronavirus (FCoV) acquires mutations in genes that code for example the Spike (S) protein and 3c (Bank-Wolf et al., 2014; Chang et al., 2012; Vennema, 1999). As there still are no treatment options or vaccines that would effectively protect felines from this disease, the pathogenesis and possible risk factors are the only ways to indirectly protect from the disease in domestic cat populations. If we can understand the risk factors to develop the disease the number of affected cats dying could be decreased, thus saving multiple pets’ lives. As we know quite much of how FCoV develops into FIPV there still is limited knowledge on why these mutations take place and that is why even research of pure statistical nature is of importance. Through statistics can individual elements, such as connections between prevalences of the viruses and individuals’ profiles, be observed from the FIP viewpoint and thus determine if they are significant in the diseases development or just anomalies which cannot be applied to a larger scale. The aim of this work is to identify possible risk factors for the development of FIP. |
| format | First cycle, G2E |
| id | RepoSLU14405 |
| institution | Swedish University of Agricultural Sciences |
| language | Swedish Inglés |
| publishDate | 2019 |
| publishDateSort | 2019 |
| record_format | eprints |
| spelling | RepoSLU144052019-04-26T01:00:34Z https://stud.epsilon.slu.se/14405/ Pathogenesis and risk factors of feline infectious peritonitis Arkela, Kristian Animal diseases Feline infectious peritonitis (FIP) is a fatal disease amongst both domesticated and wild felines. Pathogenesis behind FIP is not completely clear, but the consensus states that Feline coronavirus (FCoV) acquires mutations in genes that code for example the Spike (S) protein and 3c (Bank-Wolf et al., 2014; Chang et al., 2012; Vennema, 1999). As there still are no treatment options or vaccines that would effectively protect felines from this disease, the pathogenesis and possible risk factors are the only ways to indirectly protect from the disease in domestic cat populations. If we can understand the risk factors to develop the disease the number of affected cats dying could be decreased, thus saving multiple pets’ lives. As we know quite much of how FCoV develops into FIPV there still is limited knowledge on why these mutations take place and that is why even research of pure statistical nature is of importance. Through statistics can individual elements, such as connections between prevalences of the viruses and individuals’ profiles, be observed from the FIP viewpoint and thus determine if they are significant in the diseases development or just anomalies which cannot be applied to a larger scale. The aim of this work is to identify possible risk factors for the development of FIP. Feline infektiös peritonit (FIP) är en dödlig virussjukdom hos katter som utvecklas från Feline coronavirus (FCoV). Viruset muterar i den icke-strukturella 3c-genen och den strukturella Spike-genen (S) vilket leder till virulens och en oftast dödlig sjukdom, i kontrast till den milda enteriten som FCoV orsakar. FCoV sprids oftast fecal-oralt men kan även spridas via kattens saliv medan FIP inte verkar kunna spridas efter att mutationerna har skett. FCoV kan infektera värddjuret under hela livstiden och kan spridas hela tiden från de så kallade tysta bärarna, vilka kan vara helt symtomfria. FIPV kan påverka och infektera praktiskt taget vilket organ som helst, vilket ger en komplex sjukdomsbild och därför kan FIP blandas ihop med andra sjukdomar såsom rabies, vilket kan göra en diagnostisering extremt svår. FIPs patogenes är fortfarande oklar, vilket gör att de flesta riskfaktorer är mestadels baserat på statistiska sannolikheter och många studier motsäger varandra i avseende på ålder, kön, ras och populationstäthet. Svårigheten i diagnostisering kan förvränga statistiken, något som även påverkar studiernas precision, vilket gör att många aspekter på FIP är oklara. 2019-04-23 First cycle, G2E NonPeerReviewed application/pdf sv https://stud.epsilon.slu.se/14405/7/Arkela_K_190407.pdf Arkela, Kristian, 2019. Pathogenesis and risk factors of feline infectious peritonitis. First cycle, G2E. Uppsala: (VH) > Dept. of Biomedical Sciences and Veterinary Public Health (until 231231) <https://stud.epsilon.slu.se/view/divisions/OID-713.html> urn:nbn:se:slu:epsilon-s-10365 eng |
| spellingShingle | Animal diseases Arkela, Kristian Pathogenesis and risk factors of feline infectious peritonitis |
| title | Pathogenesis and risk factors of feline infectious peritonitis |
| title_full | Pathogenesis and risk factors of feline infectious peritonitis |
| title_fullStr | Pathogenesis and risk factors of feline infectious peritonitis |
| title_full_unstemmed | Pathogenesis and risk factors of feline infectious peritonitis |
| title_short | Pathogenesis and risk factors of feline infectious peritonitis |
| title_sort | pathogenesis and risk factors of feline infectious peritonitis |
| topic | Animal diseases |
| url | https://stud.epsilon.slu.se/14405/ https://stud.epsilon.slu.se/14405/ |