Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning
In the dog breed Nova Scotia Duck Tolling Retriever (NSDTR) several dogs suffer from joint pain and possibly pain from the muscles. This diffuse disease is called Immune-mediated Non- Erosive Arthritis in Nova Scotia Duck Tolling Retriever. The disease is most likely of autoimmune nature where t...
| Autor principal: | |
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| Formato: | L3 |
| Lenguaje: | sueco Inglés |
| Publicado: |
SLU/Dept. of Clinical Sciences (until 231231)
2007
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| Materias: |
| _version_ | 1855571921388699648 |
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| author | Axelsson, Jennie |
| author_browse | Axelsson, Jennie |
| author_facet | Axelsson, Jennie |
| author_sort | Axelsson, Jennie |
| collection | Epsilon Archive for Student Projects |
| description | In the dog breed Nova Scotia Duck Tolling Retriever (NSDTR)
several dogs suffer from joint pain and possibly pain from the
muscles. This diffuse disease is called Immune-mediated Non-
Erosive Arthritis in Nova Scotia Duck Tolling Retriever.
The disease is most likely of autoimmune nature where the etiology
still is unknown. The musculoskeletal symptoms of stiffness and
shifting lameness are intermittently seen. Some dogs also have
dermatological changes and some dogs suffer from pain when
opening their mouth.
The study included 20 diseased and 20 healthy NSDTR. The purpose
was to describe immune-mediated arthritis in NSDTR based on
symptoms, results of analysis and effect of treatment.
Among the diseased dogs 65% had serum positive for antinuclear
antibodies by indirect immunofluorescense (IIF) ANA-test. All the
healthy dogs were ANA-negative. The fluorescence-pattern of the
ANA-test in the NSDTRs were variable and no connection between
symptoms, results of ANA-analysis and effect of treatment were
found. The high number of ANA-positive dogs suffering from the
disease and the high incidence of musculoskeletal symptoms may
confirm that immune mediated arthritis in NSDTR possibly could be
an SLE (Systemic Lupus Erythematosus)-related disease.
Hematology, biochemistry and urine analysis were generally normal
in both the diseased and the healthy dogs.
Radiological examination, analysis of synovia and post-mortem
examination indicates that immune-mediated non-erosive arthritis in
NSDTR is an immune-mediated non-erosive arthritis.
The dogs have been treated with NSAID and/or prednisolone.
Generally the effect of NSAID was insufficient in relieving the dogs
symptoms. Cortisone gave a much better initial effect though it was
difficult to evaluate the effects of cortisone in the long term.
In the future it would be interesting to examine joints and synovia
from a greater number of dogs suffering from the disease. Also
analysis of cytokines and genetic investigations are exiting tools in
order to get further information about immune-mediated non-erosive
arthritis in NSDTR. |
| format | L3 |
| id | RepoSLU11697 |
| institution | Swedish University of Agricultural Sciences |
| language | swe Inglés |
| publishDate | 2007 |
| publishDateSort | 2007 |
| publisher | SLU/Dept. of Clinical Sciences (until 231231) |
| publisherStr | SLU/Dept. of Clinical Sciences (until 231231) |
| record_format | eprints |
| spelling | RepoSLU116972017-11-23T12:52:52Z Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning Axelsson, Jennie Nova Scotia Duck Tolling Retriever tollarsjuka autoimmunitet ledsmärta polyartrit In the dog breed Nova Scotia Duck Tolling Retriever (NSDTR) several dogs suffer from joint pain and possibly pain from the muscles. This diffuse disease is called Immune-mediated Non- Erosive Arthritis in Nova Scotia Duck Tolling Retriever. The disease is most likely of autoimmune nature where the etiology still is unknown. The musculoskeletal symptoms of stiffness and shifting lameness are intermittently seen. Some dogs also have dermatological changes and some dogs suffer from pain when opening their mouth. The study included 20 diseased and 20 healthy NSDTR. The purpose was to describe immune-mediated arthritis in NSDTR based on symptoms, results of analysis and effect of treatment. Among the diseased dogs 65% had serum positive for antinuclear antibodies by indirect immunofluorescense (IIF) ANA-test. All the healthy dogs were ANA-negative. The fluorescence-pattern of the ANA-test in the NSDTRs were variable and no connection between symptoms, results of ANA-analysis and effect of treatment were found. The high number of ANA-positive dogs suffering from the disease and the high incidence of musculoskeletal symptoms may confirm that immune mediated arthritis in NSDTR possibly could be an SLE (Systemic Lupus Erythematosus)-related disease. Hematology, biochemistry and urine analysis were generally normal in both the diseased and the healthy dogs. Radiological examination, analysis of synovia and post-mortem examination indicates that immune-mediated non-erosive arthritis in NSDTR is an immune-mediated non-erosive arthritis. The dogs have been treated with NSAID and/or prednisolone. Generally the effect of NSAID was insufficient in relieving the dogs symptoms. Cortisone gave a much better initial effect though it was difficult to evaluate the effects of cortisone in the long term. In the future it would be interesting to examine joints and synovia from a greater number of dogs suffering from the disease. Also analysis of cytokines and genetic investigations are exiting tools in order to get further information about immune-mediated non-erosive arthritis in NSDTR. Inom rasen Nova Scotia Duck Tolling Retriever drabbas vissa hundar av ett diffust sjukdomstillstånd med smärta från leder och eventuellt muskulatur, vilket ofta kallas för tollarsjuka. Tollarsjuka har en misstänkt autoimmun karaktär där etiologin fortfarande är okänd. Symtombilden som utgörs av vandrande hälta och stelhet uppvisas intermittent. Några hundar har även hudförändringar och problem med att öppna munnen. Studien innefattar 20 stycken friska hundar av rasen Nova Scotia Duck Tolling Retriever s.k. tollare och 20 stycken sjuka tollare drabbade av misstänkt tollarsjuka. Syftet var att beskriva tollarsjuka utifrån sjukdomsutveckling, provresultat och effekt av insatt behandling. Det immunologiska s.k. ANA-testet gav positivt utslag hos ca. 65 % av tollarna drabbade av tollarsjuka medan alla friska hundarna var negativa. Detta tillsammans med en symtombild framförallt begränsad till rörelseorganen skulle kunna tala för att tollarsjuka är en s.k. SLE-relaterad sjukdom. Fluorescensmönster som studerats vid ANA-testen hos tollare varierar dock och kan ej kopplas till symtombild, provsvar eller behandlingssvar. Hematologi, klinisk kemiska blodparametrar samt urinanalyser är generellt normala hos såväl sjuka som friska tollare. Röntgenundersökning av smärtande leder samt sektionsfynd och synovia från en hund indikerar att de tollarsjuka hundarna drabbas av en immunmedierad non-erosiv artrit. Hundarna har behandlats med NSAID och/eller kortison. Generellt verkar responsen på NSAID vara dålig medan kortisonbehandling ger en bättre effekt initialt. Analys av IL-6 i serum visar ej skillnad mellan de friska och sjuka hundarna. Fler studier krävs för att ytterligare utveckla diagnostiken vid s.k. tollarsjuka. I framtiden vore det intressant att studera leder och synovia från ett större antal tollarsjuka hundar samt undersöka förekomst av ytterligare cytokiner i blodet hos hundarna. Genetiska studier av tollarrasen vore ytterligare ett intressant verktyg att tillgå för att bidra till ökad kunskap kring sjukdomen. SLU/Dept. of Clinical Sciences (until 231231) 2007 L3 swe eng https://stud.epsilon.slu.se/11697/ |
| spellingShingle | Nova Scotia Duck Tolling Retriever tollarsjuka autoimmunitet ledsmärta polyartrit Axelsson, Jennie Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning |
| title | Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning |
| title_full | Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning |
| title_fullStr | Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning |
| title_full_unstemmed | Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning |
| title_short | Tollarsjuka hos Nova Scotia Duck Tolling Retriever : en sjukdomsbeskrivning |
| title_sort | tollarsjuka hos nova scotia duck tolling retriever : en sjukdomsbeskrivning |
| topic | Nova Scotia Duck Tolling Retriever tollarsjuka autoimmunitet ledsmärta polyartrit |