Niveles sanguíneos de ampicilina en pollos de engorde
Ampicillin has shown be usseful in the treatment of sicknees infections of respiratory tract of broilers. Dosage administration is based in terapeutical clinical efficacy, but there is know very little about the serum concentrations, and in another corporeal tissues. The aim of this work was blood c...
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| Format: | article |
| Language: | Español |
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Instituto Colombiano Agropecuario
2019
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| Online Access: | http://hdl.handle.net/20.500.12324/35475 |
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RepoAGROSAVIA35475 |
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dspace |
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Corporación Colombiana de Investigación Agropecuaria |
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Repositorio AGROSAVIA |
| language |
Español |
| topic |
Alimentación animal - L02 Alimentación de los animales Pollo de engorde Suero sanguíneo Penicilina Antibióticos Avicultura Ganadería y especies menores |
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Alimentación animal - L02 Alimentación de los animales Pollo de engorde Suero sanguíneo Penicilina Antibióticos Avicultura Ganadería y especies menores Marín L., Salomón García M., Luis F. Niveles sanguíneos de ampicilina en pollos de engorde |
| description |
Ampicillin has shown be usseful in the treatment of sicknees infections of respiratory tract of broilers. Dosage administration is based in terapeutical clinical efficacy, but there is know very little about the serum concentrations, and in another corporeal tissues. The aim of this work was blood concentrations specifity of the ampicillin in 90 broilers during 49 days when by oral means was given to the dosage of 10, 25 and 40 mg/kg of living weight. This chickens were weight homogenizazed and random entirely chosen with factorial arrangements of 4 x 5 with 5 repetitions and 1 chicken by each repetitions; 15 of this chickens were used as a control, and therefore none of this received antibiotical treatment. Blood samples were obtained after 1/2, 1, 2, 4 and 8 hours medicamental postadministration. Significatives differences were observed by dosage effect of ampicillin studied about the himself concentration in the blood (P 'K 0.01). The time has a significative meaning about the concentration of ampicillin activity in blood (P<0.05). Time ampicillin interactions was no significative difference. The in blood serum averages were of 0.471, 0.841 and 1.459 mcg/ml for dosages of 10, 25 and 40 mg/kg of living weight. Dosage of 40 mg/kg was found in concentrations of serum under 5 mcgfml at different times, which suggested to give a higher dosage than the normally used, to get in concordance with the minimal inhibitory concentration (MIC) and to obtain higher concentrations in vitro, determined for the main germs agains which ampicillin is active. |
| format |
article |
| author |
Marín L., Salomón García M., Luis F. |
| author_facet |
Marín L., Salomón García M., Luis F. |
| author_sort |
Marín L., Salomón |
| title |
Niveles sanguíneos de ampicilina en pollos de engorde |
| title_short |
Niveles sanguíneos de ampicilina en pollos de engorde |
| title_full |
Niveles sanguíneos de ampicilina en pollos de engorde |
| title_fullStr |
Niveles sanguíneos de ampicilina en pollos de engorde |
| title_full_unstemmed |
Niveles sanguíneos de ampicilina en pollos de engorde |
| title_sort |
niveles sanguíneos de ampicilina en pollos de engorde |
| publisher |
Instituto Colombiano Agropecuario |
| publishDate |
2019 |
| url |
http://hdl.handle.net/20.500.12324/35475 |
| work_keys_str_mv |
AT marinlsalomon nivelessanguineosdeampicilinaenpollosdeengorde AT garciamluisf nivelessanguineosdeampicilinaenpollosdeengorde AT marinlsalomon bloodlevelsampicillininbroilers AT garciamluisf bloodlevelsampicillininbroilers |
| _version_ |
1808108109762134016 |
| spelling |
RepoAGROSAVIA354752022-04-07T19:19:14Z Niveles sanguíneos de ampicilina en pollos de engorde Blood levels ampicillin in broilers Marín L., Salomón García M., Luis F. Alimentación animal - L02 Alimentación de los animales Pollo de engorde Suero sanguíneo Penicilina Antibióticos Avicultura Ganadería y especies menores Ampicillin has shown be usseful in the treatment of sicknees infections of respiratory tract of broilers. Dosage administration is based in terapeutical clinical efficacy, but there is know very little about the serum concentrations, and in another corporeal tissues. The aim of this work was blood concentrations specifity of the ampicillin in 90 broilers during 49 days when by oral means was given to the dosage of 10, 25 and 40 mg/kg of living weight. This chickens were weight homogenizazed and random entirely chosen with factorial arrangements of 4 x 5 with 5 repetitions and 1 chicken by each repetitions; 15 of this chickens were used as a control, and therefore none of this received antibiotical treatment. Blood samples were obtained after 1/2, 1, 2, 4 and 8 hours medicamental postadministration. Significatives differences were observed by dosage effect of ampicillin studied about the himself concentration in the blood (P 'K 0.01). The time has a significative meaning about the concentration of ampicillin activity in blood (P<0.05). Time ampicillin interactions was no significative difference. The in blood serum averages were of 0.471, 0.841 and 1.459 mcg/ml for dosages of 10, 25 and 40 mg/kg of living weight. Dosage of 40 mg/kg was found in concentrations of serum under 5 mcgfml at different times, which suggested to give a higher dosage than the normally used, to get in concordance with the minimal inhibitory concentration (MIC) and to obtain higher concentrations in vitro, determined for the main germs agains which ampicillin is active. La ampicilina ha resultado valiosa en el tratamiento de enfermedades infecciosas de las aves, especialmente en los procesos respiratorios. Sin embargo, los regímenes de tratamiento anatinfeccioso en esta especie han sido señalados con base en la eficacia terapéutica, conociéndose poco sobre la concentración alcanzable en sangre y demás tejidos corporales de los antimicrobianos comúnmente utilizados. El objetivo del presente trabajo fue determinar los niveles sanguíneos de ampicilina en pollos de 49 días de edad, administrada por vía oral en dosis de 10, 25 y 40 mg/kg de peso vivo. De un total de 90 pollos, 75 fueron asignados completamente al azar con arreglo factorial de 4 x 5, con cinco repeticiones y un pollo por cada repetición, sirviendo 15 como control experimental, los cuales no recibieron tratamiento. Los tiempos de muestreo fueron a la 1/2, 1, 2, 4 y 8 horas postadministración del antibiótico. Se observaron diferencias significativas por efecto de las dosis de ampicilina estudiadas sobre la concentración de la misma en sangre (P<0.01). El tiempo tuvo un efecto significativo sobre la concentración de ampicilina activa en la sangre (P<0.05). La interacción de ampicilina por tiempo no fue significativa. Los promedios en mcg de ampicilina/ml de suero fueron 0.471, 0.841 y 1.459 para las dosis de 10, 25 y 40 mg de antibiótico/kg de peso vivo de las aves respectivamente, independiente del tiempo. Con la dosis máxima evaluada de 40 mg/kg de peso vivo se detectaron niveles del antibiótico en el suero de los pollos en concentraciones por debajo de 5 mcg/ml a los diferentes tiempos, lo que sugiere el empleo de una dosificación mayor a la actualmente empleada, tendiente a alcanzar un nivel más alto en sangre que esté en concordancia con las concentraciones mínimas inhibitorias (MIC) determinadas in vitro para los principales gérmenes contra los cuales la ampicilina es activa Avicultura 2019-09-21T00:30:17Z 2019-09-21T00:30:17Z 1990 article Artículo científico http://purl.org/coar/resource_type/c_2df8fbb1 info:eu-repo/semantics/article https://purl.org/redcol/resource_type/ART http://purl.org/coar/version/c_970fb48d4fbd8a85 0018 - 8794 http://hdl.handle.net/20.500.12324/35475 16547 reponame:Biblioteca Digital Agropecuaria de Colombia repourl:https://repository.agrosavia.co instname:Corporación colombiana de investigación agropecuaria AGROSAVIA spa Revista ICA 2 87 93 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Acceso a texto completo info:eu-repo/semantics/openAccess application/pdf application/pdf Colombia Instituto Colombiano Agropecuario Bogotá (Colombia) Revista ICA; Vol. 25, Núm. 2 (1990): Revista ICA (Abril-Junio);p. 87-93 |