| Sumario: | Consumption of dietary ellagitannins (ETs) could be associated mainly with prevention of
cardiovascular diseases and regulation of hormone-dependent cancers. Nonetheless, ETs
are not bioavailable as such; therefore, after being partially converted into ellagic acid (EA)
in the upper gastrointestinal (GI) tract, they undergo sequential bioconversion in the colon
by gut microbiota into urolithins, a more bioavailable and bioactive group of molecules that
persist up to 4 days at relatively high concentrations in urine. Variability of urolithin
excretion in urine is high and three main groups, “no or low urolithin excreters,”
“predominantly UA derivatives excreters” and “predominantly UB derivatives excreters,”
were observed on a cohort of 26 healthy volunteers.
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