Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress
The effect of Argentine propolis extracts against enzymes related to metabolic syndrome and oxidative stress, as well as the botanical origin of raw propolis, were studied. Histological and chemical analyses of propolis samples revealed that the botanical origin is Zuccagnia punctata , an Argentine...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/7555 https://onlinelibrary.wiley.com/doi/abs/10.1111/1750-3841.15323 https://doi.org/10.1111/1750-3841.15323 |
| _version_ | 1855484032166395904 |
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| author | Salas, Ana Lilia Mercado, María Inés Orqueda, Maria Eugenia Correa Uriburu, Florencia García, Maria Elena Pérez, María Jorgelina Alvarez, María de los Angeles Ponessa, Graciela I. Maldonado, Luis Maria Zampini, Iris Catiana Isla, María Inés |
| author_browse | Alvarez, María de los Angeles Correa Uriburu, Florencia García, Maria Elena Isla, María Inés Maldonado, Luis Maria Mercado, María Inés Orqueda, Maria Eugenia Ponessa, Graciela I. Pérez, María Jorgelina Salas, Ana Lilia Zampini, Iris Catiana |
| author_facet | Salas, Ana Lilia Mercado, María Inés Orqueda, Maria Eugenia Correa Uriburu, Florencia García, Maria Elena Pérez, María Jorgelina Alvarez, María de los Angeles Ponessa, Graciela I. Maldonado, Luis Maria Zampini, Iris Catiana Isla, María Inés |
| author_sort | Salas, Ana Lilia |
| collection | INTA Digital |
| description | The effect of Argentine propolis extracts against enzymes related to metabolic syndrome and oxidative stress, as well as the botanical origin of raw propolis, were studied. Histological and chemical analyses of propolis samples revealed that the botanical origin is Zuccagnia punctata , an Argentine medicinal plant. The melissopalynological analysis showed both pollen grains of Z. punctata and the other plant species. This result indicates that the differences found in the botanical remains compared to the palynological studies may have been caused by the bees selecting resinous shrubs mainly of Z. punctata for the production of propolis and other plants with flowers for the production of honey. The richness of propolis was remarkable in two flavonoid precursors (2´,4´‐dihydroxy‐3´‐methoxychalcone, 2´,4´‐dihydroxychalcone), the major chemical components of Z. punctata . The hydroalcoholic extracts of Argentine propolis and Z. punctata were able to inhibit enzymes associated with the metabolic syndrome, including α‐glucosidase, α‐amylase and lipase, with IC50 values between 7 to 14, 37 to 48, and 13 to 28 µg/mL, respectively. Biological activity was mainly attributed to chalcones. Oxygen and nitrogen reactive species scavenging activity was determined by the assays of superoxide radical (O2•−), hydroxyl radical (HO•), hydrogen peroxide (H2O2), nitric oxide (NO•), and cation radical (ABTS•+). Results showed SC50 values between 115 to 278, 12.50 to 46; 39 to 92; 50 to 104.50 and 23 to 33.75 µg/mL, respectively. This study suggests for the first time that propolis from Argentina is highly effective in inhibiting enzymes related to the metabolic syndrome and in free‐radical scavenging that would justify its use as a dietary supplement or as a functional ingredient in special food. Practical Application: Propolis from Catamarca, Argentina, is traditionally used as medicine and food. Its botanical origin is Zuccagnia punctata , an endemic plant species popularly used as a medicine in Argentina. Propolis has the ability to regulate the activity of enzymes involved in the carbohydrate and lipid metabolism, and consequently in metabolic syndrome. Besides, its antioxidant capacity makes it a natural product that can be used as a dietary supplement or as a functional ingredient in special foods. It is important to highlight that in the Argentine Food Code, propolis was incorporated in 2008 as a dietary supplement and the present results give major added value to this product. |
| format | Artículo |
| id | INTA7555 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA75552020-07-15T12:57:12Z Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress Salas, Ana Lilia Mercado, María Inés Orqueda, Maria Eugenia Correa Uriburu, Florencia García, Maria Elena Pérez, María Jorgelina Alvarez, María de los Angeles Ponessa, Graciela I. Maldonado, Luis Maria Zampini, Iris Catiana Isla, María Inés Propóleos Alimentos Sanos Estrés Oxidativo Trastornos Metabólicos Propolis Health Foods Oxidative Stress Metabolic Disorders Zuccagnia Alimentos Funcionales The effect of Argentine propolis extracts against enzymes related to metabolic syndrome and oxidative stress, as well as the botanical origin of raw propolis, were studied. Histological and chemical analyses of propolis samples revealed that the botanical origin is Zuccagnia punctata , an Argentine medicinal plant. The melissopalynological analysis showed both pollen grains of Z. punctata and the other plant species. This result indicates that the differences found in the botanical remains compared to the palynological studies may have been caused by the bees selecting resinous shrubs mainly of Z. punctata for the production of propolis and other plants with flowers for the production of honey. The richness of propolis was remarkable in two flavonoid precursors (2´,4´‐dihydroxy‐3´‐methoxychalcone, 2´,4´‐dihydroxychalcone), the major chemical components of Z. punctata . The hydroalcoholic extracts of Argentine propolis and Z. punctata were able to inhibit enzymes associated with the metabolic syndrome, including α‐glucosidase, α‐amylase and lipase, with IC50 values between 7 to 14, 37 to 48, and 13 to 28 µg/mL, respectively. Biological activity was mainly attributed to chalcones. Oxygen and nitrogen reactive species scavenging activity was determined by the assays of superoxide radical (O2•−), hydroxyl radical (HO•), hydrogen peroxide (H2O2), nitric oxide (NO•), and cation radical (ABTS•+). Results showed SC50 values between 115 to 278, 12.50 to 46; 39 to 92; 50 to 104.50 and 23 to 33.75 µg/mL, respectively. This study suggests for the first time that propolis from Argentina is highly effective in inhibiting enzymes related to the metabolic syndrome and in free‐radical scavenging that would justify its use as a dietary supplement or as a functional ingredient in special food. Practical Application: Propolis from Catamarca, Argentina, is traditionally used as medicine and food. Its botanical origin is Zuccagnia punctata , an endemic plant species popularly used as a medicine in Argentina. Propolis has the ability to regulate the activity of enzymes involved in the carbohydrate and lipid metabolism, and consequently in metabolic syndrome. Besides, its antioxidant capacity makes it a natural product that can be used as a dietary supplement or as a functional ingredient in special foods. It is important to highlight that in the Argentine Food Code, propolis was incorporated in 2008 as a dietary supplement and the present results give major added value to this product. EEA Famaillá Fil: Salas, Ana Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales; Argentina Fil: Mercado María Inés. Fundación Miguel Lillo. Instituto de Morfología Vegetal, Tucumán, Argentina. Fil: Orqueda, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina Fil: Correa Uriburu, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales; Argentina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: García, María Elena. Fundación Miguel Lillo. Instituto de Morfología Vegetal, Tucumán, Argentina. Fil: Pérez, Maria Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina Fil: Alvarez, María de los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina Fil: Ponessa, Graciela I. Fundación Miguel Lillo. Instituto de Morfología Vegetal, Tucumán, Argentina Fil: Maldonado, Luis Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales; Argentina. Fundación Miguel Lillo. Instituto de Morfología Vegetal, Tucumán, Argentina. Fil: Isla, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales; Argentina. Fundación Miguel Lillo. Instituto de Morfología Vegetal, Tucumán, Argentina. 2020-07-15T12:51:14Z 2020-07-15T12:51:14Z 2020-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/7555 https://onlinelibrary.wiley.com/doi/abs/10.1111/1750-3841.15323 0022-1147 1750-3841 https://doi.org/10.1111/1750-3841.15323 eng info:eu-repo/semantics/restrictedAccess application/pdf Wiley Journal of Food Science (First published: 06 July 2020) |
| spellingShingle | Propóleos Alimentos Sanos Estrés Oxidativo Trastornos Metabólicos Propolis Health Foods Oxidative Stress Metabolic Disorders Zuccagnia Alimentos Funcionales Salas, Ana Lilia Mercado, María Inés Orqueda, Maria Eugenia Correa Uriburu, Florencia García, Maria Elena Pérez, María Jorgelina Alvarez, María de los Angeles Ponessa, Graciela I. Maldonado, Luis Maria Zampini, Iris Catiana Isla, María Inés Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress |
| title | Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress |
| title_full | Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress |
| title_fullStr | Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress |
| title_full_unstemmed | Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress |
| title_short | Zuccagnia‐type Propolis from Argentina: A potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress |
| title_sort | zuccagnia type propolis from argentina a potential functional ingredient in food to pathologies associated to metabolic syndrome and oxidative stress |
| topic | Propóleos Alimentos Sanos Estrés Oxidativo Trastornos Metabólicos Propolis Health Foods Oxidative Stress Metabolic Disorders Zuccagnia Alimentos Funcionales |
| url | http://hdl.handle.net/20.500.12123/7555 https://onlinelibrary.wiley.com/doi/abs/10.1111/1750-3841.15323 https://doi.org/10.1111/1750-3841.15323 |
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