Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution
During the 2000–2001 epidemic of Foot-and-Mouth Disease Virus (FMDV) in Argentina, two FMDV serotype A viruses were identified among others. Since different pathogenic properties between these virus strains were noticed in cattle, we evaluated several biological properties and features of FMDV A/Arg...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0168170209003864 http://hdl.handle.net/20.500.12123/5311 https://doi.org/10.1016/j.virusres.2009.10.013 |
| _version_ | 1855483599453683712 |
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| author | Garcia Nuñez, Maria Soledad Konig, Guido Alberto Berinstein, Analia Carrillo, Elisa Cristina |
| author_browse | Berinstein, Analia Carrillo, Elisa Cristina Garcia Nuñez, Maria Soledad Konig, Guido Alberto |
| author_facet | Garcia Nuñez, Maria Soledad Konig, Guido Alberto Berinstein, Analia Carrillo, Elisa Cristina |
| author_sort | Garcia Nuñez, Maria Soledad |
| collection | INTA Digital |
| description | During the 2000–2001 epidemic of Foot-and-Mouth Disease Virus (FMDV) in Argentina, two FMDV serotype A viruses were identified among others. Since different pathogenic properties between these virus strains were noticed in cattle, we evaluated several biological properties and features of FMDV A/Arg/00 and FMDV A/Arg/01 in order to compare these viruses in terms of virulence and pathogenicity. Our results indicate that FMDV A/Arg/00 grows less efficiently than FMDV A/Arg/01, exemplified by smaller sized plaques, retarded one-step growth curves and overall low viral yields. Also, FMDV A/Arg/00 displayed the lowest specific infectivity in suckling mice requiring 50-fold more infectious particles than FMDV A/Arg/01 to generate a LD50 in suckling mice. Finally, FMDV A/Arg/00 did not cause death in adult C57Bl/6 mice even at high doses (107–106 PFU) whereas FMDV A/Arg/01 resulted lethal in doses as low as 102 PFU. Overall, we were able to demonstrate that these virus strains differ from each other in terms of virulence and pathogenicity. |
| format | Artículo |
| id | INTA5311 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA53112019-06-13T14:04:55Z Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution Garcia Nuñez, Maria Soledad Konig, Guido Alberto Berinstein, Analia Carrillo, Elisa Cristina Enfermedades de los Animales Virus Fiebre Aftosa Fiebre Aftosa Serotipos Virulencia Animal Diseases Aphthovirus Foot and Mouth Disease Serotypes Virulence During the 2000–2001 epidemic of Foot-and-Mouth Disease Virus (FMDV) in Argentina, two FMDV serotype A viruses were identified among others. Since different pathogenic properties between these virus strains were noticed in cattle, we evaluated several biological properties and features of FMDV A/Arg/00 and FMDV A/Arg/01 in order to compare these viruses in terms of virulence and pathogenicity. Our results indicate that FMDV A/Arg/00 grows less efficiently than FMDV A/Arg/01, exemplified by smaller sized plaques, retarded one-step growth curves and overall low viral yields. Also, FMDV A/Arg/00 displayed the lowest specific infectivity in suckling mice requiring 50-fold more infectious particles than FMDV A/Arg/01 to generate a LD50 in suckling mice. Finally, FMDV A/Arg/00 did not cause death in adult C57Bl/6 mice even at high doses (107–106 PFU) whereas FMDV A/Arg/01 resulted lethal in doses as low as 102 PFU. Overall, we were able to demonstrate that these virus strains differ from each other in terms of virulence and pathogenicity. Instituto de Biotecnología Fil: Garcia Nuñez, Maria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Berinstein, Analia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Carrillo, Elisa Cristina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2019-06-13T14:03:03Z 2019-06-13T14:03:03Z 2010-01 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0168170209003864 http://hdl.handle.net/20.500.12123/5311 0168-1702 https://doi.org/10.1016/j.virusres.2009.10.013 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Virus Research 147 (1) : 149-152 (January 2010) |
| spellingShingle | Enfermedades de los Animales Virus Fiebre Aftosa Fiebre Aftosa Serotipos Virulencia Animal Diseases Aphthovirus Foot and Mouth Disease Serotypes Virulence Garcia Nuñez, Maria Soledad Konig, Guido Alberto Berinstein, Analia Carrillo, Elisa Cristina Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution |
| title | Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution |
| title_full | Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution |
| title_fullStr | Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution |
| title_full_unstemmed | Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution |
| title_short | Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution |
| title_sort | differences in the virulence of two strains of foot and mouth disease virus serotype a with the same spatiotemporal distribution |
| topic | Enfermedades de los Animales Virus Fiebre Aftosa Fiebre Aftosa Serotipos Virulencia Animal Diseases Aphthovirus Foot and Mouth Disease Serotypes Virulence |
| url | https://www.sciencedirect.com/science/article/pii/S0168170209003864 http://hdl.handle.net/20.500.12123/5311 https://doi.org/10.1016/j.virusres.2009.10.013 |
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