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Selection of highly susceptible cell lines to Foot and Mouth disease virus infection

Different non-established cultures were examined to find those that showed high sensitivity to Foot and Mouth Disease Virus (FMDV). Ovine kidney cultures showed high sensitivity to types A, O and C, and were suitable to detect viral infection in samples of animal, as well as cell culture origin. The...

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Main Authors: Zabal, Osvaldo Alfredo, Fondevila, Norberto Antonio
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: Scientific Research 2019
Subjects:
Enfermedades de los Animales
Fiebre Aftosa
Cultivo de Tejidos
Células
Ovinos
Animal Diseases
Foot and Mouth Disease
Tissue Culture
Cells
Sheep
Online Access:https://www.scirp.org/journal/PaperInformation.aspx?PaperID=36381
http://hdl.handle.net/20.500.12123/4277
https://doi.org/10.4236/ojvm.2013.35042
Summary:Different non-established cultures were examined to find those that showed high sensitivity to Foot and Mouth Disease Virus (FMDV). Ovine kidney cultures showed high sensitivity to types A, O and C, and were suitable to detect viral infection in samples of animal, as well as cell culture origin. The level of detection in this system was up to ten times higher than in BHK21 cells, which were commonly used for FMDV isolation and production. Viral production levels in ovine kidney cultures ranged from similar to twice as high as in BHK21. Ovine kidney cultures maintained these characteristics for at least 18 passages, allowing their use as an alternative system for FMDV diagnoses.

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