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ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis

Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the de...

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Main Authors: Blanco, Federico Carlos, Soria, Marcelo Abel, Klepp, Laura Ines, Bigi, Fabiana
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: Karger 2018
Subjects:
Transcription
Cattle
Immune Response
Animal Diseases
Transcripción
Mycobacterium bovis
Ganado Bovino
Respuesta Inmunológica
Tuberculosis
Enfermedades de los Animales
Online Access:https://www.karger.com/Article/Abstract/479183
http://hdl.handle.net/20.500.12123/3986
https://doi.org/10.1159/000479183
Summary:Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.

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