ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the de...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Karger
2018
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| Online Access: | https://www.karger.com/Article/Abstract/479183 http://hdl.handle.net/20.500.12123/3986 https://doi.org/10.1159/000479183 |
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| author | Blanco, Federico Carlos Soria, Marcelo Abel Klepp, Laura Ines Bigi, Fabiana |
| author_browse | Bigi, Fabiana Blanco, Federico Carlos Klepp, Laura Ines Soria, Marcelo Abel |
| author_facet | Blanco, Federico Carlos Soria, Marcelo Abel Klepp, Laura Ines Bigi, Fabiana |
| author_sort | Blanco, Federico Carlos |
| collection | INTA Digital |
| description | Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB. |
| format | info:ar-repo/semantics/artículo |
| id | INTA3986 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Karger |
| publisherStr | Karger |
| record_format | dspace |
| spelling | INTA39862018-11-28T15:33:42Z ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis Blanco, Federico Carlos Soria, Marcelo Abel Klepp, Laura Ines Bigi, Fabiana Transcription Cattle Immune Response Animal Diseases Transcripción Mycobacterium bovis Ganado Bovino Respuesta Inmunológica Tuberculosis Enfermedades de los Animales Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB. Instituto de Biotecnología Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina 2018-11-28T15:28:27Z 2018-11-28T15:28:27Z 2017-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.karger.com/Article/Abstract/479183 http://hdl.handle.net/20.500.12123/3986 1660-2412 https://doi.org/10.1159/000479183 eng info:eu-repograntAgreement/INTA/PNBIO/1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario. info:eu-repo/semantics/restrictedAccess application/pdf Karger Journal of Molecular Microbiology and Biotechnology 27 (4) : 237-245 (Diciembre 2017) |
| spellingShingle | Transcription Cattle Immune Response Animal Diseases Transcripción Mycobacterium bovis Ganado Bovino Respuesta Inmunológica Tuberculosis Enfermedades de los Animales Blanco, Federico Carlos Soria, Marcelo Abel Klepp, Laura Ines Bigi, Fabiana ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis |
| title | ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis |
| title_full | ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis |
| title_fullStr | ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis |
| title_full_unstemmed | ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis |
| title_short | ERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosis |
| title_sort | erap1 and pde8a are downregulated in cattle protected against bovine tuberculosis |
| topic | Transcription Cattle Immune Response Animal Diseases Transcripción Mycobacterium bovis Ganado Bovino Respuesta Inmunológica Tuberculosis Enfermedades de los Animales |
| url | https://www.karger.com/Article/Abstract/479183 http://hdl.handle.net/20.500.12123/3986 https://doi.org/10.1159/000479183 |
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