Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion

The cost-efficient degradation of xylan to fermentable sugars is of particular interest in second generation bioethanol production, feed, food, and pulp and paper industries. Multiple potentially secreted enzymes involved in polysaccharide deconstruction are encoded in the genome of Paenibacillus sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghio, Silvina, Ontañon, Ornella Mailén, Piccinni, Florencia Elizabeth, Marrero Diaz De Vill, Rubén, Talia, Paola Mónica, Grasso, Daniel Horacio, Campos, Eleonora
Formato: info:ar-repo/semantics/artículo
Lenguaje:Inglés
Publicado: Springer 2018
Materias:
Acceso en línea:http://hdl.handle.net/20.500.12123/2913
https://link.springer.com/article/10.1007%2Fs12155-017-9887-7
https://doi.org/10.1007/s12155-017-9887-7
_version_ 1855035049761570816
author Ghio, Silvina
Ontañon, Ornella Mailén
Piccinni, Florencia Elizabeth
Marrero Diaz De Vill, Rubén
Talia, Paola Mónica
Grasso, Daniel Horacio
Campos, Eleonora
author_browse Campos, Eleonora
Ghio, Silvina
Grasso, Daniel Horacio
Marrero Diaz De Vill, Rubén
Ontañon, Ornella Mailén
Piccinni, Florencia Elizabeth
Talia, Paola Mónica
author_facet Ghio, Silvina
Ontañon, Ornella Mailén
Piccinni, Florencia Elizabeth
Marrero Diaz De Vill, Rubén
Talia, Paola Mónica
Grasso, Daniel Horacio
Campos, Eleonora
author_sort Ghio, Silvina
collection INTA Digital
description The cost-efficient degradation of xylan to fermentable sugars is of particular interest in second generation bioethanol production, feed, food, and pulp and paper industries. Multiple potentially secreted enzymes involved in polysaccharide deconstruction are encoded in the genome of Paenibacillus sp. A59, a xylanolytic soil bacterium, such as three endoxylanases, seven GH43 β-xylosidases, and two GH30 glucuronoxylanases. In secretome analysis of xylan cultures, ten glycoside hydrolases were identified, including the three predicted endoxylanases, confirming their active role. The two uni-modular xylanases, a 32-KDa GH10 and a 20-KDa GH11, were recombinantly expressed and their activity on xylan was confirmed (106 and 85 IU/mg, respectively), with differences in their activity pattern. Both endoxylanases released mainly xylobiose (X2) and xylotriose (X3) from xylan and pre-treated biomasses (wheat straw, barley straw, and sweet corn cob), although only rGH10XynA released xylose (X1). rGH10XynA presented optimal conditions at pH 6, with thermal stability at 45–50 °C, while rGH11XynB showed activity in a wider range of pH, from 5 to 9, and was thermostable only at 45 °C. Moreover, GH11XynB presented sigmoidal kinetics on xylan, indicating possible cooperative binding, which was further supported by the structural model. This study provides a detailed analysis of the complete set of carbohydrate-active enzymes encoded in Paenibacillus sp. A59 genome and those effectively implicated in hemicellulose hydrolysis, contributing to understanding the mechanisms necessary for the bioconversion of this polysaccharide. Moreover, the two main free secreted xylanases, rGH10XynA and rGH11XynB, were fully characterized, supporting their potential application in industrial bioprocesses on lignocellulosic biomass.
format info:ar-repo/semantics/artículo
id INTA2913
institution Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina)
language Inglés
publishDate 2018
publishDateRange 2018
publishDateSort 2018
publisher Springer
publisherStr Springer
record_format dspace
spelling INTA29132018-07-30T13:51:11Z Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion Ghio, Silvina Ontañon, Ornella Mailén Piccinni, Florencia Elizabeth Marrero Diaz De Vill, Rubén Talia, Paola Mónica Grasso, Daniel Horacio Campos, Eleonora Paenibacillus Bioconversión Biomasa Biomass Bioconversion Endoxylanases GH10 GH11 The cost-efficient degradation of xylan to fermentable sugars is of particular interest in second generation bioethanol production, feed, food, and pulp and paper industries. Multiple potentially secreted enzymes involved in polysaccharide deconstruction are encoded in the genome of Paenibacillus sp. A59, a xylanolytic soil bacterium, such as three endoxylanases, seven GH43 β-xylosidases, and two GH30 glucuronoxylanases. In secretome analysis of xylan cultures, ten glycoside hydrolases were identified, including the three predicted endoxylanases, confirming their active role. The two uni-modular xylanases, a 32-KDa GH10 and a 20-KDa GH11, were recombinantly expressed and their activity on xylan was confirmed (106 and 85 IU/mg, respectively), with differences in their activity pattern. Both endoxylanases released mainly xylobiose (X2) and xylotriose (X3) from xylan and pre-treated biomasses (wheat straw, barley straw, and sweet corn cob), although only rGH10XynA released xylose (X1). rGH10XynA presented optimal conditions at pH 6, with thermal stability at 45–50 °C, while rGH11XynB showed activity in a wider range of pH, from 5 to 9, and was thermostable only at 45 °C. Moreover, GH11XynB presented sigmoidal kinetics on xylan, indicating possible cooperative binding, which was further supported by the structural model. This study provides a detailed analysis of the complete set of carbohydrate-active enzymes encoded in Paenibacillus sp. A59 genome and those effectively implicated in hemicellulose hydrolysis, contributing to understanding the mechanisms necessary for the bioconversion of this polysaccharide. Moreover, the two main free secreted xylanases, rGH10XynA and rGH11XynB, were fully characterized, supporting their potential application in industrial bioprocesses on lignocellulosic biomass. Instituto de Suelos Fil: Ghio, Silvina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; Argentina Fil: Ontañon, Ornella Mailén. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Piccinni, Florencia Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marrero Diaz de Villegas, Rubén. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Talia, Paola Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Grasso, Daniel Horacio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina Fil: Campos, Eleonora. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2018-07-30T13:42:37Z 2018-07-30T13:42:37Z 2018-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/2913 https://link.springer.com/article/10.1007%2Fs12155-017-9887-7 1939-1234 https://doi.org/10.1007/s12155-017-9887-7 eng info:eu-repo/semantics/restrictedAccess application/pdf Springer BioEnergy research 11 (1) : 174–190. (March 2018)
spellingShingle Paenibacillus
Bioconversión
Biomasa
Biomass
Bioconversion
Endoxylanases
GH10
GH11
Ghio, Silvina
Ontañon, Ornella Mailén
Piccinni, Florencia Elizabeth
Marrero Diaz De Vill, Rubén
Talia, Paola Mónica
Grasso, Daniel Horacio
Campos, Eleonora
Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion
title Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion
title_full Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion
title_fullStr Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion
title_full_unstemmed Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion
title_short Paenibacillus sp. A59 GH10 and GH11 extracellular endoxylanases: application in biomass bioconversion
title_sort paenibacillus sp a59 gh10 and gh11 extracellular endoxylanases application in biomass bioconversion
topic Paenibacillus
Bioconversión
Biomasa
Biomass
Bioconversion
Endoxylanases
GH10
GH11
url http://hdl.handle.net/20.500.12123/2913
https://link.springer.com/article/10.1007%2Fs12155-017-9887-7
https://doi.org/10.1007/s12155-017-9887-7
work_keys_str_mv AT ghiosilvina paenibacillusspa59gh10andgh11extracellularendoxylanasesapplicationinbiomassbioconversion
AT ontanonornellamailen paenibacillusspa59gh10andgh11extracellularendoxylanasesapplicationinbiomassbioconversion
AT piccinniflorenciaelizabeth paenibacillusspa59gh10andgh11extracellularendoxylanasesapplicationinbiomassbioconversion
AT marrerodiazdevillruben paenibacillusspa59gh10andgh11extracellularendoxylanasesapplicationinbiomassbioconversion
AT taliapaolamonica paenibacillusspa59gh10andgh11extracellularendoxylanasesapplicationinbiomassbioconversion
AT grassodanielhoracio paenibacillusspa59gh10andgh11extracellularendoxylanasesapplicationinbiomassbioconversion
AT camposeleonora paenibacillusspa59gh10andgh11extracellularendoxylanasesapplicationinbiomassbioconversion