Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
Abstract Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal t...
| Main Authors: | , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Elsevier
2025
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/24782 https://www.elsevier.es/en-revista-revista-argentina-microbiologia-argentinean-372-pdf-S0325754125000902 https://doi.org/10.1016/j.ram.2025.07.006 |
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| author | Etchecopaz, Alenadro A. Di Ciaccio, Lucia Soledad Hermida Alava, Katherine Fortunato, Reneé H. Salvat, Adriana Elisabeth Nusblat, Alejandro E. Cuestas, Maria L. |
| author_browse | Cuestas, Maria L. Di Ciaccio, Lucia Soledad Etchecopaz, Alenadro A. Fortunato, Reneé H. Hermida Alava, Katherine Nusblat, Alejandro E. Salvat, Adriana Elisabeth |
| author_facet | Etchecopaz, Alenadro A. Di Ciaccio, Lucia Soledad Hermida Alava, Katherine Fortunato, Reneé H. Salvat, Adriana Elisabeth Nusblat, Alejandro E. Cuestas, Maria L. |
| author_sort | Etchecopaz, Alenadro A. |
| collection | INTA Digital |
| description | Abstract Infections caused by the genus Candida have acquired considerable significance in
recent years due to the enhanced susceptibility of immunocompromised hosts. There have been
increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has
become a priority. In this study, we assessed the antifungal activity of seven methanolic extracts
from the Argentinian native plants Peltophorum dubium, Schinus areira, Parastrephia quadran gularis and Lantana balansae against clinical isolates of different wild-type and MDR isolates
of Candida. Synergism with fluconazole was also evaluated. All plant extracts showed antifun gal activities against different Candida species, including MDR isolates such as C. haemulonii.
Highly active extracts from these native plants provide promising sources of compounds for
potentiating the antifungal effect of fluconazole. Further investigation of the chemical con stituents of the extracts and their cytotoxicity is needed to develop plant-derived anti-Candida
agents. |
| format | Artículo |
| id | INTA24782 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA247822025-12-26T23:14:35Z Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species Etchecopaz, Alenadro A. Di Ciaccio, Lucia Soledad Hermida Alava, Katherine Fortunato, Reneé H. Salvat, Adriana Elisabeth Nusblat, Alejandro E. Cuestas, Maria L. Planta Antifúngica Propiedad Antimicosica Resistencia a Medicamentos Antifungal Plants Antifungal Properties Drug Resistance Plantas Nativas Argentinas Candida Sp. Sinergismo Argentinian Native Plants Synergism Abstract Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has become a priority. In this study, we assessed the antifungal activity of seven methanolic extracts from the Argentinian native plants Peltophorum dubium, Schinus areira, Parastrephia quadran gularis and Lantana balansae against clinical isolates of different wild-type and MDR isolates of Candida. Synergism with fluconazole was also evaluated. All plant extracts showed antifun gal activities against different Candida species, including MDR isolates such as C. haemulonii. Highly active extracts from these native plants provide promising sources of compounds for potentiating the antifungal effect of fluconazole. Further investigation of the chemical con stituents of the extracts and their cytotoxicity is needed to develop plant-derived anti-Candida agents. Instituto de Patobiología Fil: Etchecopaz, Alejandro A. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina Fil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina Fil: Etchecopaz, Alejandro A. Universidad de Buenos Aires (UBA). Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina Fil: Di Ciaccio, Lucía Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Hermida Alava, Katherine. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina Fil: Hermida Alava, Katherine. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina Fil: Fortunato, Reneé H. Instituto de Botánica Darwinion; Argentina Fil: Salvat, Adriana Elisabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Nusblat, Alejandro E. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Nanobiotecnología (NANOBIOTEC); Argentina Fil: Nusblat, Alejandro E. Universidad de Buenos Aires (UBA). Instituto de Nanobiotecnología (NANOBIOTEC); Argentina Fil: Cuestas, Maria L. Consejo Nacional de Investigaciones Cientícas y Técnicas (CONICET). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina Fil: Cuestas, Maria L. Universidad de Buenos Aires (UBA). Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM); Argentina 2025-12-26T23:09:33Z 2025-12-26T23:09:33Z 2025-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/24782 https://www.elsevier.es/en-revista-revista-argentina-microbiologia-argentinean-372-pdf-S0325754125000902 0325-7541 https://doi.org/10.1016/j.ram.2025.07.006 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Revista Argentina de Microbiología 10:1016 (Julio 2025) |
| spellingShingle | Planta Antifúngica Propiedad Antimicosica Resistencia a Medicamentos Antifungal Plants Antifungal Properties Drug Resistance Plantas Nativas Argentinas Candida Sp. Sinergismo Argentinian Native Plants Synergism Etchecopaz, Alenadro A. Di Ciaccio, Lucia Soledad Hermida Alava, Katherine Fortunato, Reneé H. Salvat, Adriana Elisabeth Nusblat, Alejandro E. Cuestas, Maria L. Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species |
| title | Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species |
| title_full | Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species |
| title_fullStr | Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species |
| title_full_unstemmed | Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species |
| title_short | Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species |
| title_sort | extracts from argentinian native plants exhibit antifungal activity against multidrug resistant candida species |
| topic | Planta Antifúngica Propiedad Antimicosica Resistencia a Medicamentos Antifungal Plants Antifungal Properties Drug Resistance Plantas Nativas Argentinas Candida Sp. Sinergismo Argentinian Native Plants Synergism |
| url | http://hdl.handle.net/20.500.12123/24782 https://www.elsevier.es/en-revista-revista-argentina-microbiologia-argentinean-372-pdf-S0325754125000902 https://doi.org/10.1016/j.ram.2025.07.006 |
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