Extracts from Argentinian native plants exhibit antifungal activity against multidrug-resistant Candida species
Abstract Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal t...
| Autores principales: | , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/24782 https://www.elsevier.es/en-revista-revista-argentina-microbiologia-argentinean-372-pdf-S0325754125000902 https://doi.org/10.1016/j.ram.2025.07.006 |
| Sumario: | Abstract Infections caused by the genus Candida have acquired considerable significance in
recent years due to the enhanced susceptibility of immunocompromised hosts. There have been
increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hur dle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has
become a priority. In this study, we assessed the antifungal activity of seven methanolic extracts
from the Argentinian native plants Peltophorum dubium, Schinus areira, Parastrephia quadran gularis and Lantana balansae against clinical isolates of different wild-type and MDR isolates
of Candida. Synergism with fluconazole was also evaluated. All plant extracts showed antifun gal activities against different Candida species, including MDR isolates such as C. haemulonii.
Highly active extracts from these native plants provide promising sources of compounds for
potentiating the antifungal effect of fluconazole. Further investigation of the chemical con stituents of the extracts and their cytotoxicity is needed to develop plant-derived anti-Candida
agents. |
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