Genetic and antigenic diversity of Bubaline alphaherpesvirus 1
Bubaline alphaherpesvirus 1 (BuHV-1) is a virus that belongs to the Varicellovirus genus within the Alphaherpesvirinae subfamily. While BuHV-1 infections in water buffaloes (Bubalus bubalis) are often subclinical, clinical manifestations have been reported. This study provides complete genome sequen...
| Autores principales: | , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/23446 https://www.mdpi.com/1999-4915/17/8/1110 https://doi.org/10.3390/v17081110 |
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| author | Tau, Rocio Lucia Marandino, Ana Torales, Fatima Anabel Campos, Fabricio Roehe, Paulo Michel Konrad, Jose Luis Romera, Sonia Alejandra Perez, Ruben Maidana, Silvina Soledad |
| author_browse | Campos, Fabricio Konrad, Jose Luis Maidana, Silvina Soledad Marandino, Ana Perez, Ruben Roehe, Paulo Michel Romera, Sonia Alejandra Tau, Rocio Lucia Torales, Fatima Anabel |
| author_facet | Tau, Rocio Lucia Marandino, Ana Torales, Fatima Anabel Campos, Fabricio Roehe, Paulo Michel Konrad, Jose Luis Romera, Sonia Alejandra Perez, Ruben Maidana, Silvina Soledad |
| author_sort | Tau, Rocio Lucia |
| collection | INTA Digital |
| description | Bubaline alphaherpesvirus 1 (BuHV-1) is a virus that belongs to the Varicellovirus genus within the Alphaherpesvirinae subfamily. While BuHV-1 infections in water buffaloes (Bubalus bubalis) are often subclinical, clinical manifestations have been reported. This study provides complete genome sequences of five BuHV-1 strains isolated in Argentina, marking the first genomic characterization of BuHV-1 from the Americas. Phylogenetic reconstructions based on whole-genome and coding sequences, along with analyses of glycoproteins C, D, and E, identified a distinct clade and divergent strains. Comparative genomic analyses with publicly available BuHV-1 and Bovine alphaherpesvirus 5 (BoHV-5) sequences showed nucleotide divergence of up to 1.3% among BuHV-1 strains, indicating significant intraspecific genetic diversity. Cross-neutralization assays revealed variable relationships between BuHV-1 and BoHV-5 strains. Some Argentinian BuHV-1 strains exhibited significant antigenic subtype differences compared to Bovine alphaherpesvirus 1 (BoHV-1). Recombination analyses uncovered events between BuHV-1 and bovine herpesviruses, suggesting a complex evolutionary history within mixed farming systems. The findings indicate that the monophyletic BuHV-1 clade, including the reference BuHV-1 isolate, is representative of the BuHV-1 species. The remaining strains, provisionally classified as BuHV-1 indeterminate (BuHV-1i), can be categorized based on specific clinical and antigenic properties. The identified heterogeneity has significant implications for diagnostic accuracy, vaccine development, and disease management strategies in buffalo populations worldwide. |
| format | Artículo |
| id | INTA23446 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA234462025-08-18T10:14:26Z Genetic and antigenic diversity of Bubaline alphaherpesvirus 1 Tau, Rocio Lucia Marandino, Ana Torales, Fatima Anabel Campos, Fabricio Roehe, Paulo Michel Konrad, Jose Luis Romera, Sonia Alejandra Perez, Ruben Maidana, Silvina Soledad Herpesviridae Genetic Variation Genetic Diversity (resource) Antigens Antigen Antibody Reactions Neutralization Phylogenetic Analysis Recombination Water Buffaloes Variación Genética Diversidad Genética (recurso) Antígenos Reacción Antígeno Anticuerpo Neutralización Análisis Filogenético Recombinación Búfalo de Agua Bubaline Alphaherpesvirus 1 Bubaline alphaherpesvirus 1 (BuHV-1) is a virus that belongs to the Varicellovirus genus within the Alphaherpesvirinae subfamily. While BuHV-1 infections in water buffaloes (Bubalus bubalis) are often subclinical, clinical manifestations have been reported. This study provides complete genome sequences of five BuHV-1 strains isolated in Argentina, marking the first genomic characterization of BuHV-1 from the Americas. Phylogenetic reconstructions based on whole-genome and coding sequences, along with analyses of glycoproteins C, D, and E, identified a distinct clade and divergent strains. Comparative genomic analyses with publicly available BuHV-1 and Bovine alphaherpesvirus 5 (BoHV-5) sequences showed nucleotide divergence of up to 1.3% among BuHV-1 strains, indicating significant intraspecific genetic diversity. Cross-neutralization assays revealed variable relationships between BuHV-1 and BoHV-5 strains. Some Argentinian BuHV-1 strains exhibited significant antigenic subtype differences compared to Bovine alphaherpesvirus 1 (BoHV-1). Recombination analyses uncovered events between BuHV-1 and bovine herpesviruses, suggesting a complex evolutionary history within mixed farming systems. The findings indicate that the monophyletic BuHV-1 clade, including the reference BuHV-1 isolate, is representative of the BuHV-1 species. The remaining strains, provisionally classified as BuHV-1 indeterminate (BuHV-1i), can be categorized based on specific clinical and antigenic properties. The identified heterogeneity has significant implications for diagnostic accuracy, vaccine development, and disease management strategies in buffalo populations worldwide. Instituto de Virología Fil: Tau, Rocio Lucia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Tau, Rocio Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marandino, Ana. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Torales, Fatima Anabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Torales, Fatima Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Campos, Fabricio. Universidade Federal do Rio Grande do Sul. Institute of Basic Health Sciences. Department of Microbiology, Immunology and Parasitology. Laboratory of Bioinformatics & Biotechnology; Brasil Fil: Roehe, Paulo Michel. Universidade Federal do Rio Grande do Sul. Institute of Basic Health Sciences. Department of Microbiology, Immunology and Parasitology. Virology Laboratory; Brasil Fil: Konrad, José Luis. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Romera, Sonia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Romera, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Romera, Sonia Alejandra. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinarias. Instituto de Investigación Veterinaria; Argentina Fil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Maidana, Silvina Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Maidana, Silvina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Maidana, Silvina Soledad. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinarias. Instituto de Investigación Veterinaria; Argentina 2025-08-18T10:08:56Z 2025-08-18T10:08:56Z 2025-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/23446 https://www.mdpi.com/1999-4915/17/8/1110 1999-4915 https://doi.org/10.3390/v17081110 eng info:eu-repograntAgreement/INTA/2023-PD-L06-I114, Desarrollo y aplicación de métodos diagnósticos y epidemiológicos para la producción pecuaria sustentable y agroalimentaria en humanos con foco en Una Salud info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 17 (8) : 1110 (August 2025) |
| spellingShingle | Herpesviridae Genetic Variation Genetic Diversity (resource) Antigens Antigen Antibody Reactions Neutralization Phylogenetic Analysis Recombination Water Buffaloes Variación Genética Diversidad Genética (recurso) Antígenos Reacción Antígeno Anticuerpo Neutralización Análisis Filogenético Recombinación Búfalo de Agua Bubaline Alphaherpesvirus 1 Tau, Rocio Lucia Marandino, Ana Torales, Fatima Anabel Campos, Fabricio Roehe, Paulo Michel Konrad, Jose Luis Romera, Sonia Alejandra Perez, Ruben Maidana, Silvina Soledad Genetic and antigenic diversity of Bubaline alphaherpesvirus 1 |
| title | Genetic and antigenic diversity of Bubaline alphaherpesvirus 1 |
| title_full | Genetic and antigenic diversity of Bubaline alphaherpesvirus 1 |
| title_fullStr | Genetic and antigenic diversity of Bubaline alphaherpesvirus 1 |
| title_full_unstemmed | Genetic and antigenic diversity of Bubaline alphaherpesvirus 1 |
| title_short | Genetic and antigenic diversity of Bubaline alphaherpesvirus 1 |
| title_sort | genetic and antigenic diversity of bubaline alphaherpesvirus 1 |
| topic | Herpesviridae Genetic Variation Genetic Diversity (resource) Antigens Antigen Antibody Reactions Neutralization Phylogenetic Analysis Recombination Water Buffaloes Variación Genética Diversidad Genética (recurso) Antígenos Reacción Antígeno Anticuerpo Neutralización Análisis Filogenético Recombinación Búfalo de Agua Bubaline Alphaherpesvirus 1 |
| url | http://hdl.handle.net/20.500.12123/23446 https://www.mdpi.com/1999-4915/17/8/1110 https://doi.org/10.3390/v17081110 |
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