Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precu...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Springer Nature
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/22352 https://www.nature.com/articles/s41587-025-02611-1 https://doi.org/10.1038/s41587-025-02611-1 |
| _version_ | 1855486918901366784 |
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| author | Griffiths, Cara A. Xiaochao, Xue Miret, Javier A. Salvagiotti, Fernando Acevedo-Siaca, Liana G. Gimeno, Jacinta Reynolds, Matthew P. Hassall, Kirsty L. Halsey, Kirstie Puranik, Swati Oszvald, Maria Kurup, Smita Davis, Benjamin G. Paul, Matthew J. |
| author_browse | Acevedo-Siaca, Liana G. Davis, Benjamin G. Gimeno, Jacinta Griffiths, Cara A. Halsey, Kirstie Hassall, Kirsty L. Kurup, Smita Miret, Javier A. Oszvald, Maria Paul, Matthew J. Puranik, Swati Reynolds, Matthew P. Salvagiotti, Fernando Xiaochao, Xue |
| author_facet | Griffiths, Cara A. Xiaochao, Xue Miret, Javier A. Salvagiotti, Fernando Acevedo-Siaca, Liana G. Gimeno, Jacinta Reynolds, Matthew P. Hassall, Kirsty L. Halsey, Kirstie Puranik, Swati Oszvald, Maria Kurup, Smita Davis, Benjamin G. Paul, Matthew J. |
| author_sort | Griffiths, Cara A. |
| collection | INTA Digital |
| description | Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops. |
| format | Artículo |
| id | INTA22352 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | dspace |
| spelling | INTA223522025-05-20T12:27:51Z Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials Griffiths, Cara A. Xiaochao, Xue Miret, Javier A. Salvagiotti, Fernando Acevedo-Siaca, Liana G. Gimeno, Jacinta Reynolds, Matthew P. Hassall, Kirsty L. Halsey, Kirstie Puranik, Swati Oszvald, Maria Kurup, Smita Davis, Benjamin G. Paul, Matthew J. Trigo Rendimiento Fitomejoramiento Trehalosa Variedades Wheat Yields Plant Breeding Trehalose Varieties Trehalose 6-phosphate Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops. EEA Oliveros Fil: Griffiths, Cara A. Rothamsted Research; Reino Unido Fil: Xiaochao, Xue. University of Oxford. Department of Chemistry; Reino Unido Fil: Miret, Javier A. Rothamsted Research; Reino Unido Fil: Salvagiotti, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; Argentina Fil: Salvagiotti, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Acevedo-Siaca, Liana G. Wageningen University. Horticulture and Product Physiology; Países Bajos Fil: Acevedo-Siaca, Liana G. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México Fil: Gimeno, Jacinta. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México Fil: Reynolds, Matthew P. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México Fil: Hassall, Kirsty L. University of Warwick. Department of Statistics; Reino Unido Fil: Hassall, Kirsty L. Rothamsted Research; Reino Unido Fil: Halsey, Kirstie. Rothamsted Research; Reino Unido Fil: Puranik, Swati. Rothamsted Research; Reino Unido Fil: Oszvald, Maria. Rothamsted Research; Reino Unido Fil: Kurup, Smita. Rothamsted Research; Reino Unido Fil: Davis, Benjamin G. University of Oxford. Department of Chemistry; Reino Unido Fil: Davis, Benjamin G. University of Oxford. Department of Pharmacology; Reino Unido Fil: Davis, Benjamin G. Rosalind Franklin Institute; Reino Unido Fil: Paul, Matthew J. Rothamsted Research; Reino Unido 2025-05-20T12:25:26Z 2025-05-20T12:25:26Z 2025-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/22352 https://www.nature.com/articles/s41587-025-02611-1 1087-0156 1546-1696 https://doi.org/10.1038/s41587-025-02611-1 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Springer Nature Nature Biotechnology : 1-29. (Published: 29 April 2025) |
| spellingShingle | Trigo Rendimiento Fitomejoramiento Trehalosa Variedades Wheat Yields Plant Breeding Trehalose Varieties Trehalose 6-phosphate Griffiths, Cara A. Xiaochao, Xue Miret, Javier A. Salvagiotti, Fernando Acevedo-Siaca, Liana G. Gimeno, Jacinta Reynolds, Matthew P. Hassall, Kirsty L. Halsey, Kirstie Puranik, Swati Oszvald, Maria Kurup, Smita Davis, Benjamin G. Paul, Matthew J. Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials |
| title | Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials |
| title_full | Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials |
| title_fullStr | Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials |
| title_full_unstemmed | Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials |
| title_short | Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials |
| title_sort | membrane permeable trehalose 6 phosphate precursor spray increases wheat yields in field trials |
| topic | Trigo Rendimiento Fitomejoramiento Trehalosa Variedades Wheat Yields Plant Breeding Trehalose Varieties Trehalose 6-phosphate |
| url | http://hdl.handle.net/20.500.12123/22352 https://www.nature.com/articles/s41587-025-02611-1 https://doi.org/10.1038/s41587-025-02611-1 |
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