Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (AST...
| Autores principales: | , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Elsevier
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/22235 https://www.sciencedirect.com/science/article/abs/pii/S0955286325000877 https://doi.org/10.1016/j.jnutbio.2025.109924 |
| _version_ | 1855038538554277888 |
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| author | Vargas, Matias Rodrigo Ferreira, María del Rosario Collins, Pablo D’Alessandro, Maria Eugenia |
| author_browse | Collins, Pablo D’Alessandro, Maria Eugenia Ferreira, María del Rosario Vargas, Matias Rodrigo |
| author_facet | Vargas, Matias Rodrigo Ferreira, María del Rosario Collins, Pablo D’Alessandro, Maria Eugenia |
| author_sort | Vargas, Matias Rodrigo |
| collection | INTA Digital |
| description | The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia. |
| format | info:ar-repo/semantics/artículo |
| id | INTA22235 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA222352025-05-12T11:52:04Z Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats Vargas, Matias Rodrigo Ferreira, María del Rosario Collins, Pablo D’Alessandro, Maria Eugenia Astaxantina Tejido Adiposo Adiposidad Rata Sucrosa Astaxanthin Adipose Tissue Adiposity Rats Sucrose Freshwater Crustaceans Marisco de Agua Dulce The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia. EEA Rafaela Fil: Vargas, Matias Rodrigo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina Fil: Ferreira, María del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina Fil: Ferreira, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Collins, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Centro Operativo Experimental A.G.; Argentina Fil: Collins, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: D’Alessandro, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina Fil: D’Alessandro, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2025-05-12T11:46:48Z 2025-05-12T11:46:48Z 2025-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/22235 https://www.sciencedirect.com/science/article/abs/pii/S0955286325000877 0955-2863 1873-4847 https://doi.org/10.1016/j.jnutbio.2025.109924 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier The Journal of Nutritional Biochemistry 142 : 109924. (August 2025) |
| spellingShingle | Astaxantina Tejido Adiposo Adiposidad Rata Sucrosa Astaxanthin Adipose Tissue Adiposity Rats Sucrose Freshwater Crustaceans Marisco de Agua Dulce Vargas, Matias Rodrigo Ferreira, María del Rosario Collins, Pablo D’Alessandro, Maria Eugenia Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
| title | Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
| title_full | Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
| title_fullStr | Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
| title_full_unstemmed | Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
| title_short | Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
| title_sort | astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high sucrose diet fed rats |
| topic | Astaxantina Tejido Adiposo Adiposidad Rata Sucrosa Astaxanthin Adipose Tissue Adiposity Rats Sucrose Freshwater Crustaceans Marisco de Agua Dulce |
| url | http://hdl.handle.net/20.500.12123/22235 https://www.sciencedirect.com/science/article/abs/pii/S0955286325000877 https://doi.org/10.1016/j.jnutbio.2025.109924 |
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