Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated that in...
| Autores principales: | , , , , |
|---|---|
| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2025
|
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/21418 https://www.sciencedirect.com/science/article/abs/pii/S0367326X2500005X https://doi.org/10.1016/j.fitote.2025.106380 |
| _version_ | 1855038397986373632 |
|---|---|
| author | Spotorno, Viviana Graciela Roxo, Mariana Wetterauer, Bernhard Zabal, Osvaldo Alfredo Wink, Michael |
| author_browse | Roxo, Mariana Spotorno, Viviana Graciela Wetterauer, Bernhard Wink, Michael Zabal, Osvaldo Alfredo |
| author_facet | Spotorno, Viviana Graciela Roxo, Mariana Wetterauer, Bernhard Zabal, Osvaldo Alfredo Wink, Michael |
| author_sort | Spotorno, Viviana Graciela |
| collection | INTA Digital |
| description | Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated that in a PD model dietary in Caenorhabditis elegans treatment with an extract from the rhizome of Canna coccinea decreased the accumulation of α-synuclein. The extract showed low toxicity to neuro 2a cells and protected them from oxidative damage with H2O2 as a model for neurodegeneration. We studied the chemical profile of the extract using liquid chromatography couple to Mass Spectrometry. In order to characterize the herbal extract, we quantified rosmarinic acid as a marker compound and measured its antioxidant activity in vitro. Altogether, apart from its potential as a functional food, Canna coccinea may be an interesting source of secondary metabolites in the development of potential novel anti-neurodegenerative drugs. |
| format | info:ar-repo/semantics/artículo |
| id | INTA21418 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA214182025-02-24T11:04:33Z Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract Spotorno, Viviana Graciela Roxo, Mariana Wetterauer, Bernhard Zabal, Osvaldo Alfredo Wink, Michael Canna Plant Extracts Nervous System Diseases Caenorhabditis elegans Neuropathy Extractos Vegetales Trastornos del Sistema Nervioso Neuropatia Canna coccinea Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated that in a PD model dietary in Caenorhabditis elegans treatment with an extract from the rhizome of Canna coccinea decreased the accumulation of α-synuclein. The extract showed low toxicity to neuro 2a cells and protected them from oxidative damage with H2O2 as a model for neurodegeneration. We studied the chemical profile of the extract using liquid chromatography couple to Mass Spectrometry. In order to characterize the herbal extract, we quantified rosmarinic acid as a marker compound and measured its antioxidant activity in vitro. Altogether, apart from its potential as a functional food, Canna coccinea may be an interesting source of secondary metabolites in the development of potential novel anti-neurodegenerative drugs. Instituto de Recursos Biológicos Fil: Spotorno, Viviana Graciela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina Fil: Roxo, Mariana. Heidelberg University. Institute of Pharmacy and Molecular Biotechnology; Alemania Fil: Wetterauer, Bernhard. Heidelberg University. Institute of Pharmacy and Molecular Biotechnology; Alemania Fil: Zabal, Osvaldo Alfredo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Fil: Wink, Michael. Heidelberg University. Institute of Pharmacy and Molecular Biotechnology; Alemania 2025-02-24T11:02:02Z 2025-02-24T11:02:02Z 2025-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/21418 https://www.sciencedirect.com/science/article/abs/pii/S0367326X2500005X 0367-326X 1873-6971 https://doi.org/10.1016/j.fitote.2025.106380 eng info:eu-repograntAgreement/INTA/PNHFA-1106094/AR./Plataformas tecnológicas y comerciales, para aromáticas cultivadas-nativas y medicinales info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Fitoterapia 181 : 106380. (March 2025) |
| spellingShingle | Canna Plant Extracts Nervous System Diseases Caenorhabditis elegans Neuropathy Extractos Vegetales Trastornos del Sistema Nervioso Neuropatia Canna coccinea Spotorno, Viviana Graciela Roxo, Mariana Wetterauer, Bernhard Zabal, Osvaldo Alfredo Wink, Michael Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract |
| title | Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract |
| title_full | Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract |
| title_fullStr | Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract |
| title_full_unstemmed | Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract |
| title_short | Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract |
| title_sort | effects on neuroprotection and α synuclein expression of a canna coccinea rhizome extract |
| topic | Canna Plant Extracts Nervous System Diseases Caenorhabditis elegans Neuropathy Extractos Vegetales Trastornos del Sistema Nervioso Neuropatia Canna coccinea |
| url | http://hdl.handle.net/20.500.12123/21418 https://www.sciencedirect.com/science/article/abs/pii/S0367326X2500005X https://doi.org/10.1016/j.fitote.2025.106380 |
| work_keys_str_mv | AT spotornovivianagraciela effectsonneuroprotectionandasynucleinexpressionofacannacoccinearhizomeextract AT roxomariana effectsonneuroprotectionandasynucleinexpressionofacannacoccinearhizomeextract AT wetterauerbernhard effectsonneuroprotectionandasynucleinexpressionofacannacoccinearhizomeextract AT zabalosvaldoalfredo effectsonneuroprotectionandasynucleinexpressionofacannacoccinearhizomeextract AT winkmichael effectsonneuroprotectionandasynucleinexpressionofacannacoccinearhizomeextract |