Natural occurring epialleles determine vitamin E accumulation in tomato fruits
Vitamin E (VTE) content is a low heritability nutritional trait for which the genetic determinants are poorly understood. Here, we focus on a previously detected major tomato VTE quantitative trait loci (QTL; mQTL9-2-6) and identify the causal gene as one encoding a 2-methyl-6-phytylquinol methyltra...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.nature.com/articles/ncomms5027.pdf http://hdl.handle.net/20.500.12123/2094 |
| _version_ | 1855034902783721472 |
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| author | Quadrana, Leandro Daniel Almeida de Souza, Juliana Beatriz Asis, Ramón Duffy, Tomas Dominguez, Pia Guadalupe Bermudez Salazar, Luisa Conti, Gabriela Silva, Junia V. Corrêa da Peralta, Iris Edith Colot, Vincent Asurmendi, Sebastian Fernie, Alisdair R. Rossi, Magdalena Carrari, Fernando Oscar |
| author_browse | Almeida de Souza, Juliana Beatriz Asis, Ramón Asurmendi, Sebastian Bermudez Salazar, Luisa Carrari, Fernando Oscar Colot, Vincent Conti, Gabriela Dominguez, Pia Guadalupe Duffy, Tomas Fernie, Alisdair R. Peralta, Iris Edith Quadrana, Leandro Daniel Rossi, Magdalena Silva, Junia V. Corrêa da |
| author_facet | Quadrana, Leandro Daniel Almeida de Souza, Juliana Beatriz Asis, Ramón Duffy, Tomas Dominguez, Pia Guadalupe Bermudez Salazar, Luisa Conti, Gabriela Silva, Junia V. Corrêa da Peralta, Iris Edith Colot, Vincent Asurmendi, Sebastian Fernie, Alisdair R. Rossi, Magdalena Carrari, Fernando Oscar |
| author_sort | Quadrana, Leandro Daniel |
| collection | INTA Digital |
| description | Vitamin E (VTE) content is a low heritability nutritional trait for which the genetic determinants are poorly understood. Here, we focus on a previously detected major tomato VTE quantitative trait loci (QTL; mQTL9-2-6) and identify the causal gene as one encoding a 2-methyl-6-phytylquinol methyltransferase (namely VTE3(1)) that catalyses one of the final steps in the biosynthesis of γ- and α-tocopherols, which are the main forms of VTE. By reverse genetic approaches, expression analyses, siRNA profiling and DNA methylation assays, we demonstrate that mQTL9-2-6 is an expression QTL associated with differential methylation of a SINE retrotransposon located in the promoter region of VTE3(1). Promoter DNA methylation can be spontaneously reverted leading to different epialleles affecting VTE3(1) expression and VTE content in fruits. These findings indicate therefore that naturally occurring epialleles are responsible for regulation of a nutritionally important metabolic QTL and provide direct evidence of a role for epigenetics in the determination of agronomic traits. |
| format | info:ar-repo/semantics/artículo |
| id | INTA2094 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA20942018-08-06T18:39:06Z Natural occurring epialleles determine vitamin E accumulation in tomato fruits Quadrana, Leandro Daniel Almeida de Souza, Juliana Beatriz Asis, Ramón Duffy, Tomas Dominguez, Pia Guadalupe Bermudez Salazar, Luisa Conti, Gabriela Silva, Junia V. Corrêa da Peralta, Iris Edith Colot, Vincent Asurmendi, Sebastian Fernie, Alisdair R. Rossi, Magdalena Carrari, Fernando Oscar Tomate Vitamina E Loci de Rasgos Cuantitativos Fisiología Vegetal Tomatoes Vitamin E Quantitative Trait Loci Plant Physiology QTL Vitamin E (VTE) content is a low heritability nutritional trait for which the genetic determinants are poorly understood. Here, we focus on a previously detected major tomato VTE quantitative trait loci (QTL; mQTL9-2-6) and identify the causal gene as one encoding a 2-methyl-6-phytylquinol methyltransferase (namely VTE3(1)) that catalyses one of the final steps in the biosynthesis of γ- and α-tocopherols, which are the main forms of VTE. By reverse genetic approaches, expression analyses, siRNA profiling and DNA methylation assays, we demonstrate that mQTL9-2-6 is an expression QTL associated with differential methylation of a SINE retrotransposon located in the promoter region of VTE3(1). Promoter DNA methylation can be spontaneously reverted leading to different epialleles affecting VTE3(1) expression and VTE content in fruits. These findings indicate therefore that naturally occurring epialleles are responsible for regulation of a nutritionally important metabolic QTL and provide direct evidence of a role for epigenetics in the determination of agronomic traits. Instituto de Biotecnología Fil: Quadrana, Leandro Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia Fil: Almeida de Souza, Juliana Beatriz. Universidade de Sao Paulo. Instituto de Biociências. Departamento de Botânica; Brasil Fil: Asis, Ramón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina Fil: Duffy, Tomás. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Dominguez, Pia Guadalupe. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bermudez Salazar, Luisa Fernanda. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomía; Argentina Fil: Conti, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomía; Argentina Fil: Silva, Junia V. Corrêa da. Universidade de Sao Paulo. Instituto de Biociências. Departamento de Botânica; Brasil Fil: Peralta, Iris Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; Argentina Fil: Colot, Vincent. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia Fil: Asurmendi, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fernie, Alisdair R. Max Planck Institute for Molecular Plant Physiology; Alemania Fil: Rossi, Magdalena. Universidade de São Pablo. Instituto de Biociências. Departamento de Botânica; Brasil Fil: Carrari, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomía; Argentina 2018-03-21T14:57:15Z 2018-03-21T14:57:15Z 2014-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.nature.com/articles/ncomms5027.pdf http://hdl.handle.net/20.500.12123/2094 2041-1723 doi:10.1038/ncomms5027 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Nature Communications 5 : Article number: 4027 (2014) |
| spellingShingle | Tomate Vitamina E Loci de Rasgos Cuantitativos Fisiología Vegetal Tomatoes Vitamin E Quantitative Trait Loci Plant Physiology QTL Quadrana, Leandro Daniel Almeida de Souza, Juliana Beatriz Asis, Ramón Duffy, Tomas Dominguez, Pia Guadalupe Bermudez Salazar, Luisa Conti, Gabriela Silva, Junia V. Corrêa da Peralta, Iris Edith Colot, Vincent Asurmendi, Sebastian Fernie, Alisdair R. Rossi, Magdalena Carrari, Fernando Oscar Natural occurring epialleles determine vitamin E accumulation in tomato fruits |
| title | Natural occurring epialleles determine vitamin E accumulation in tomato fruits |
| title_full | Natural occurring epialleles determine vitamin E accumulation in tomato fruits |
| title_fullStr | Natural occurring epialleles determine vitamin E accumulation in tomato fruits |
| title_full_unstemmed | Natural occurring epialleles determine vitamin E accumulation in tomato fruits |
| title_short | Natural occurring epialleles determine vitamin E accumulation in tomato fruits |
| title_sort | natural occurring epialleles determine vitamin e accumulation in tomato fruits |
| topic | Tomate Vitamina E Loci de Rasgos Cuantitativos Fisiología Vegetal Tomatoes Vitamin E Quantitative Trait Loci Plant Physiology QTL |
| url | https://www.nature.com/articles/ncomms5027.pdf http://hdl.handle.net/20.500.12123/2094 |
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