Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products : potential pH-dependent inhibition explored through computer-aided drug design

Visceral Leishmaniasis (VL) is a serious public health issue, documented in more than ninety countries, where an estimated 500,000 new cases emerge each year. Regardless of novel methodologies, advancements, and experimental interventions, therapeutic limitations, and drug resistance are still chall...

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Main Authors:	Goyzueta-Mamani, Luis Daniel, Barazorda-Ccahuana, Haruna Luz, Candia-Puma, Mayron Antonio, Galdino, Alexsandro Sobreira, Machado-de-Avila, Ricardo Andrez, Giunchetti, Rodolfo Cordeiro, Medina-Franco, José L., Florin-Christensen, Mónica, Ferraz Coelho, Eduardo Antonio, Chavez Fumagalli, Miguel Angel
Format:	info:ar-repo/semantics/artículo
Language:	Inglés
Published:	Frontiers Media 2024
Subjects:	Leishmaniosis Oligosaccharides Glucosidases Computer Software Leishmania infantum Oligosacáridos Glucosidasa Programas de Ordenador Natural Products Productos Naturales
Online Access:	http://hdl.handle.net/20.500.12123/20289 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1403203/full https://doi.org/10.3389/fphar.2024.1403203