Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products : potential pH-dependent inhibition explored through computer-aided drug design

Visceral Leishmaniasis (VL) is a serious public health issue, documented in more than ninety countries, where an estimated 500,000 new cases emerge each year. Regardless of novel methodologies, advancements, and experimental interventions, therapeutic limitations, and drug resistance are still chall...

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Autores principales:	Goyzueta-Mamani, Luis Daniel, Barazorda-Ccahuana, Haruna Luz, Candia-Puma, Mayron Antonio, Galdino, Alexsandro Sobreira, Machado-de-Avila, Ricardo Andrez, Giunchetti, Rodolfo Cordeiro, Medina-Franco, José L., Florin-Christensen, Mónica, Ferraz Coelho, Eduardo Antonio, Chavez Fumagalli, Miguel Angel
Formato:	info:ar-repo/semantics/artículo
Lenguaje:	Inglés
Publicado:	Frontiers Media 2024
Materias:	Leishmaniosis Oligosaccharides Glucosidases Computer Software Leishmania infantum Oligosacáridos Glucosidasa Programas de Ordenador Natural Products Productos Naturales
Acceso en línea:	http://hdl.handle.net/20.500.12123/20289 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1403203/full https://doi.org/10.3389/fphar.2024.1403203