Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success
Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding...
| Main Authors: | , , |
|---|---|
| Format: | Artículo |
| Language: | Inglés |
| Published: |
2018
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/2005 https://doi.org/10.3389/fimmu.2016.00661 https://www.frontiersin.org/articles/10.3389/fimmu.2016.00661/full |
| _version_ | 1855482978351710208 |
|---|---|
| author | Jaworski, Juan Pablo Vendrell, Alejandrina Chiavenna, Sebastián Matias |
| author_browse | Chiavenna, Sebastián Matias Jaworski, Juan Pablo Vendrell, Alejandrina |
| author_facet | Jaworski, Juan Pablo Vendrell, Alejandrina Chiavenna, Sebastián Matias |
| author_sort | Jaworski, Juan Pablo |
| collection | INTA Digital |
| description | Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells. |
| format | Artículo |
| id | INTA2005 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA20052018-08-06T18:07:14Z Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success Jaworski, Juan Pablo Vendrell, Alejandrina Chiavenna, Sebastián Matias Virus de la Inmunodeficiencia Humana Anticuerpos Monoclonales Profilaxis de las Enfermedades Human Immunodeficiency Virus Monoclonal Antibodies Disease Prophylaxis Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells. Inst.de Virología Fil: Jaworski, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vendrell, Alejandrina. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Chiavenna, Sebastián Matias. Ferrer Advanced Biotherapeutics, Ferrer Internacional; España 2018-03-09T14:28:17Z 2018-03-09T14:28:17Z 2017 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/2005 1664-3224 https://doi.org/10.3389/fimmu.2016.00661 https://www.frontiersin.org/articles/10.3389/fimmu.2016.00661/full eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Frontiers in immunology 7 : 661 (March 2017) |
| spellingShingle | Virus de la Inmunodeficiencia Humana Anticuerpos Monoclonales Profilaxis de las Enfermedades Human Immunodeficiency Virus Monoclonal Antibodies Disease Prophylaxis Jaworski, Juan Pablo Vendrell, Alejandrina Chiavenna, Sebastián Matias Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success |
| title | Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success |
| title_full | Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success |
| title_fullStr | Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success |
| title_full_unstemmed | Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success |
| title_short | Neutralizing monoclonal antibodies to fight HIV-1 : on the threshold of success |
| title_sort | neutralizing monoclonal antibodies to fight hiv 1 on the threshold of success |
| topic | Virus de la Inmunodeficiencia Humana Anticuerpos Monoclonales Profilaxis de las Enfermedades Human Immunodeficiency Virus Monoclonal Antibodies Disease Prophylaxis |
| url | http://hdl.handle.net/20.500.12123/2005 https://doi.org/10.3389/fimmu.2016.00661 https://www.frontiersin.org/articles/10.3389/fimmu.2016.00661/full |
| work_keys_str_mv | AT jaworskijuanpablo neutralizingmonoclonalantibodiestofighthiv1onthethresholdofsuccess AT vendrellalejandrina neutralizingmonoclonalantibodiestofighthiv1onthethresholdofsuccess AT chiavennasebastianmatias neutralizingmonoclonalantibodiestofighthiv1onthethresholdofsuccess |