SARS-CoV-2 specific nanobodies neutralize different variants of concern and reduce virus load in the brain of h-ACE2 transgenic mice

Since the beginning of the COVID-19 pandemic, there has been a significant need to develop antivirals and vaccines to combat the disease. In this work, we developed llama-derived nanobodies (Nbs) directed against the receptor binding domain (RBD) and other domains of the Spike (S) protein of SARS-Co...

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Main Authors:	Pavan, Florencia, Bok, Marina, Betanzos San Juan, Rafael, Malito, Juan Pablo, Marcoppido, Gisela Ariana, Franco, Diego Rafael, Militelo, Daniela Ayelen, Schammas, Juan Manuel, Bari, Sara Elizabeth, Stone, William B., López, Krisangel, Porier, Danielle LaBrie, Muller, John Anthony, Auguste, Albert J., Yuan, Lijuan, Wigdorovitz, Andres, Parreño, Gladys Viviana, Ibañez, Lorena Itat
Format:	info:ar-repo/semantics/artículo
Language:	Inglés
Published:	MDPI 2024
Subjects:	Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Antibody Reactions Transgenic Animals Mice Nanobiotechnology Coronavirus del Síndrome Respiratorio Agudo Grave 2 Reacción Antígeno Anticuerpo Animales Transgénicos Ratón Nanobiotecnología SARS-CoV-2 Intranasal Treatment Tratamiento Intranasal
Online Access:	http://hdl.handle.net/20.500.12123/18374 https://www.mdpi.com/1999-4915/16/2/185 https://doi.org/10.3390/v16020185