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Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection

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Benznidazole and nifurtimox are the only drugs specifically approved for the treatment of Chagas disease. Both compounds are given orally in tablets, but occasionally are ineffective and cause adverse effects. Benznidazole, the first-line treatment in many countries, is a compound with low solubilit...

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Main Authors: Devies, Carolina, Simonazzi, Analía, Micheloud, Juan Francisco, Ragone, Paula Gabriela, Cid, Alicia Graciela, Sánchez Negrette, Olga, Bermúdez, José María, Parada, Luis Antonio
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: American Society of Parasitologists 2024
Subjects:
Dispersión
Improve
Treatment
Trypanosoma cruzi
Enfermedad de Chagas
Terapia
Chagas Disease
Therapy
Benznidazole
Tratamiento de las Enfermedades
Nifurtimox
Disease Treatment
Online Access:http://hdl.handle.net/20.500.12123/16803
https://bioone.org/journals/journal-of-parasitology/volume-106/issue-3/19-80/Benznidazole-Poloxamer-407-Solid-Dispersion-as-a-New-Strategy-to/10.1645/19-80.short
https://doi.org/10.1645/19-80
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