Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection

Benznidazole and nifurtimox are the only drugs specifically approved for the treatment of Chagas disease. Both compounds are given orally in tablets, but occasionally are ineffective and cause adverse effects. Benznidazole, the first-line treatment in many countries, is a compound with low solubilit...

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Autores principales:	Devies, Carolina, Simonazzi, Analía, Micheloud, Juan Francisco, Ragone, Paula Gabriela, Cid, Alicia Graciela, Sánchez Negrette, Olga, Bermúdez, José María, Parada, Luis Antonio
Formato:	info:ar-repo/semantics/artículo
Lenguaje:	Inglés
Publicado:	American Society of Parasitologists 2024
Materias:	Dispersión Improve Treatment Trypanosoma cruzi Enfermedad de Chagas Terapia Chagas Disease Therapy Benznidazole Tratamiento de las Enfermedades Nifurtimox Disease Treatment
Acceso en línea:	http://hdl.handle.net/20.500.12123/16803 https://bioone.org/journals/journal-of-parasitology/volume-106/issue-3/19-80/Benznidazole-Poloxamer-407-Solid-Dispersion-as-a-New-Strategy-to/10.1645/19-80.short https://doi.org/10.1645/19-80