Probiotic as adjuvant significantly improves protection of the Lanzhou trivalent rotavirus vaccine against heterologous challenge in a gnotobiotic pig model of human rotavirus infection and disease

This preclinical study in the gnotobiotic (Gn) pig model of human rotavirus (HRV) infection and disease evaluates the effect of probiotic Lactobacillus rhamnosus GG (LGG) as a mucosal adjuvant on the immunogenicity and cross-protective efficacy of the Lanzhou live oral trivalent (G2, G3, G4) vaccine...

Full description

Bibliographic Details

Main Authors:	Parreño, Gladys Viviana, Bai, Muqun, Liu, Fangning, Jing, Jiqiang, Olney, Erika, Li, Guohua, Wen, Ke, Yang, Xingdong, Castellucc, Tammy Bui, Kocher, Jacob F., Zhou, Xu, Yuan, Lijuan
Format:	info:ar-repo/semantics/artículo
Language:	Inglés
Published:	MDPI 2023
Subjects:	Rotavirus Probiotics Vaccine Adjuvants Gnotobiotic Animals Swine Probióticos Coadyuvantes de Vacunas Animales Notobióticos Cerdo Lactobacillus rhamnosus Infección por Rotavirus Humano Human Rotavirus Infection
Online Access:	http://hdl.handle.net/20.500.12123/16376 https://www.mdpi.com/2076-393X/10/9/1529 https://doi.org/10.3390/vaccines10091529