A new gnotobiotic pig model of P[6] human rotavirus infection and disease for preclinical evaluation of rotavirus vaccines

Human rotavirus (HRV) is a leading cause of gastroenteritis in children under 5 years of age. Licensed vaccines containing G1P[8] and G1-4P[8] strains are less efficacious against newly emerging P[6] strains, indicating an urgent need for better cross protective vaccines. Here, we report our develop...

Full description

Bibliographic Details

Main Authors:	Nyblade, Charlotte, Hensley, Casey, Parreño, Gladys Viviana, Zhou, Peng, Frazier, Maggie, Frazier, Annie, Ramesh, Ashwin, Lei, Shaohua, Degiuseppe, Juan Ignacio, Tan, Ming, Yuan, Lijuan
Format:	info:ar-repo/semantics/artículo
Language:	Inglés
Published:	MDPI 2023
Subjects:	Rotavirus Gnotobiotic Animals Diarrhoea Swine Vaccines Animales Notobióticos Diarrea Cerdo Vacuna Human Rotavirus Infection Infección por Rotavirus Humano
Online Access:	http://hdl.handle.net/20.500.12123/16366 https://www.mdpi.com/1999-4915/14/12/2803 https://doi.org/10.3390/v14122803