Phylogenetic and structural analyses of equine rotaviruses : three possible geographically related lineages
The structural analyses revealed that the aa substitutions in VP7 are in the antigenic sites and in the VP7:VP6 interaction region. In accordance, most of the aa changes in VP6 are in the top of the protein involving antigenic and VP7:VP6 interaction sites. Interestingly, the structural analyses o...
| Autores principales: | , , |
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| Formato: | info:eu-repo/semantics/article |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/1015 http://www.j-evs.com/article/S0737-0806(16)00086-1/pdf http://dx.doi.org/10.1016/j.jevs.2016.02.055 |
| Sumario: | The structural analyses revealed that the aa substitutions
in VP7 are in the antigenic sites and in the VP7:VP6
interaction region. In accordance, most of the aa changes in VP6 are in the top of the protein involving antigenic and VP7:VP6 interaction sites. Interestingly, the structural analyses of VP8* showed a few aa differences in the antigenic sites and, all equine P[12] shown the same conserved aa sequence in VP8* pocket, only observed in P[12] genotype. Our study suggest the existence of geographically related equine RVA lineages and,
describe the aa configuration of the VP8* pocket. |
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