Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
Triclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente puede reducir la infección uke fl a un nivel insignificante.
| Autores principales: | , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/1603 https://www.sciencedirect.com/science/article/pii/S0304401711000161?via%3Dihub https://doi.org/10.1016/j.vetpar.2010.12.047 |
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| author | Olaechea, Fermin Lovera, V. Larroza, Marcela Patricia Raffo, Fernando Cabrera, Raul Francisco |
| author_browse | Cabrera, Raul Francisco Larroza, Marcela Patricia Lovera, V. Olaechea, Fermin Raffo, Fernando |
| author_facet | Olaechea, Fermin Lovera, V. Larroza, Marcela Patricia Raffo, Fernando Cabrera, Raul Francisco |
| author_sort | Olaechea, Fermin |
| collection | INTA Digital |
| description | Triclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente puede reducir la infección uke fl a un nivel insignificante. |
| format | info:ar-repo/semantics/artículo |
| id | INTA1603 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| record_format | dspace |
| spelling | INTA16032019-03-21T18:21:14Z Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina) Olaechea, Fermin Lovera, V. Larroza, Marcela Patricia Raffo, Fernando Cabrera, Raul Francisco Enfermedades de los Animales Fasciola Hepatica Resistencia a la Enfermedad Ganado Bovino Animal Diseases Disease Resistance Cattle Región Patagónica Triclabendazole Triclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente puede reducir la infección uke fl a un nivel insignificante. In the winter of 2008, cattle on a farm in the province of Neuquen, Argentina died from subacute and chronic liver fluke disease despite four previous treatments with Triclabendazole (TCBZ). In the spring of 2009, a preliminary efficacy test revealed good performance using nitroxynil, whereas TCBZ efficacy was only 18% by egg counts of Fasciola eggs in the faeces. Resistance to Fasciola hepatica to TCBZ has never been reported in South America, so in January of 2010 a controlled trial was conducted to confirm and to define the degree of resistance in this herd. In a clinical trial, the fluke egg output was monitored on Days 14 and 21 and serum enzymes gamma-glutamyl transpeptidase (GGT) and glutamic-oxaloacetic transaminase (GOT) on Days 0 and 21 in 36 calves treated with TCBZ or with closantel. The results showed a reduction of 100% in fluke egg output at Days 14 and 21 for closantel. The mean epg in the TCBZ-treated groups did not decrease. Because of the fact that in this study TCBZ treatment in cattle had no effect, even at double the recommended dose, it is highly indicative that resistance of F. hepatica against TCBZ is present on this farm. The GGT and GOT levels decreased in the closantel-treated group as a result of the treatment at 21 days after dosing. To evaluate the importance of TCBZ resistance in F. hepatica in Argentina, a study on more farms from endemic areas is needed. EEA Bariloche Fil: Olaechea, Fermin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina Fil: Raffo, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina Fil: Cabrera, Raul Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo Salud Animal; Argentina 2017-10-27T11:32:52Z 2017-10-27T11:32:52Z 2011-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/1603 https://www.sciencedirect.com/science/article/pii/S0304401711000161?via%3Dihub 0304-4017 https://doi.org/10.1016/j.vetpar.2010.12.047 eng info:eu-repo/semantics/restrictedAccess application/pdf Veterinary parasitology 178 (3–4) : 364-366. (June 2011) |
| spellingShingle | Enfermedades de los Animales Fasciola Hepatica Resistencia a la Enfermedad Ganado Bovino Animal Diseases Disease Resistance Cattle Región Patagónica Triclabendazole Olaechea, Fermin Lovera, V. Larroza, Marcela Patricia Raffo, Fernando Cabrera, Raul Francisco Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina) |
| title | Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina) |
| title_full | Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina) |
| title_fullStr | Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina) |
| title_full_unstemmed | Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina) |
| title_short | Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina) |
| title_sort | resistance of fasciola hepatica against triclabendazole in cattle in patagonia argentina |
| topic | Enfermedades de los Animales Fasciola Hepatica Resistencia a la Enfermedad Ganado Bovino Animal Diseases Disease Resistance Cattle Región Patagónica Triclabendazole |
| url | http://hdl.handle.net/20.500.12123/1603 https://www.sciencedirect.com/science/article/pii/S0304401711000161?via%3Dihub https://doi.org/10.1016/j.vetpar.2010.12.047 |
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