What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
Poultry is the first source of animal protein for human consumption. In a changing world, this sector is facing new challenges, such as a projected increase in demand, higher standards of food quality and safety, and reduction of environmental impact. Chicken coccidiosis is a highly widespread enter...
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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MDPI
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/14702 https://www.mdpi.com/2075-1729/13/6/1295 https://doi.org/10.3390/life13061295 |
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| author | Britez, Jesica Daiana Rodriguez, Anabel Elisa Di Ciaccio, Lucia Soledad Marugán-Hernandez, Virginia Tomazic, Mariela Luján |
| author_browse | Britez, Jesica Daiana Di Ciaccio, Lucia Soledad Marugán-Hernandez, Virginia Rodriguez, Anabel Elisa Tomazic, Mariela Luján |
| author_facet | Britez, Jesica Daiana Rodriguez, Anabel Elisa Di Ciaccio, Lucia Soledad Marugán-Hernandez, Virginia Tomazic, Mariela Luján |
| author_sort | Britez, Jesica Daiana |
| collection | INTA Digital |
| description | Poultry is the first source of animal protein for human consumption. In a changing world, this sector is facing new challenges, such as a projected increase in demand, higher standards of food quality and safety, and reduction of environmental impact. Chicken coccidiosis is a highly widespread enteric disease caused by Eimeria spp. which causes significant economic losses to the poultry industry worldwide; however, the impact on family poultry holders or backyard production—which plays a key role in food security in small communities and involves mainly rural women—has been little explored. Coccidiosis disease is controlled by good husbandry measures, chemoprophylaxis, and/or live vaccination. The first live vaccines against chicken coccidiosis were developed in the 1950s; however, after more than seven decades, none has reached the market. Current limitations on their use have led to research in next-generation vaccines based on recombinant or live-vectored vaccines. Next-generation vaccines are required to control this complex parasitic disease, and for this purpose, protective antigens need to be identified. In this review, we have scrutinised surface proteins identified so far in Eimeria spp. affecting chickens. Most of these surface proteins are anchored to the parasite membrane by a glycosylphosphatidylinositol (GPI) molecule. The biosynthesis of GPIs, as well as the role of currently identified surface proteins and interest as vaccine candidates has been summarised. The potential role of surface proteins in drug resistance and immune escape and how these could limit the efficacy of control strategies was also discussed. |
| format | info:ar-repo/semantics/artículo |
| id | INTA14702 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA147022023-07-05T16:47:04Z What Do We Know about Surface Proteins of Chicken Parasites Eimeria? Britez, Jesica Daiana Rodriguez, Anabel Elisa Di Ciaccio, Lucia Soledad Marugán-Hernandez, Virginia Tomazic, Mariela Luján Aves de Corral Pollo Parásitos Proteínas Enfoque Una salud Poultry Chickens Parasites Eimeria Proteins Coccidiosis One Health Approach Poultry is the first source of animal protein for human consumption. In a changing world, this sector is facing new challenges, such as a projected increase in demand, higher standards of food quality and safety, and reduction of environmental impact. Chicken coccidiosis is a highly widespread enteric disease caused by Eimeria spp. which causes significant economic losses to the poultry industry worldwide; however, the impact on family poultry holders or backyard production—which plays a key role in food security in small communities and involves mainly rural women—has been little explored. Coccidiosis disease is controlled by good husbandry measures, chemoprophylaxis, and/or live vaccination. The first live vaccines against chicken coccidiosis were developed in the 1950s; however, after more than seven decades, none has reached the market. Current limitations on their use have led to research in next-generation vaccines based on recombinant or live-vectored vaccines. Next-generation vaccines are required to control this complex parasitic disease, and for this purpose, protective antigens need to be identified. In this review, we have scrutinised surface proteins identified so far in Eimeria spp. affecting chickens. Most of these surface proteins are anchored to the parasite membrane by a glycosylphosphatidylinositol (GPI) molecule. The biosynthesis of GPIs, as well as the role of currently identified surface proteins and interest as vaccine candidates has been summarised. The potential role of surface proteins in drug resistance and immune escape and how these could limit the efficacy of control strategies was also discussed. Instituto de Patobiología Fil: Britez, Jesica Daiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Britez, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Rodriguez, Anabel Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Di Ciaccio, Lucía Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Di Ciaccio, Lucía Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marugán-Hernandez, Virginia. University of London. Royal Veterinary College; Reino Unido Fil: Tomazic, Mariela Luján. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Tomazic, Mariela Luján. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tomazic, Mariela Luján. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Biotecnología; Argentina 2023-07-05T16:36:51Z 2023-07-05T16:36:51Z 2023-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/14702 https://www.mdpi.com/2075-1729/13/6/1295 2075-1729 https://doi.org/10.3390/life13061295 eng info:eu-repograntAgreement/INTA/2019-PE-E6-I113-001/2019-PE-E6-I113-001, Abordaje integral para la conservación, mejoramiento y rescate de especies amenazadas de importancia para el SAAA en diferentes ambientes info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Life 13 (6) : 1295 (May 2023) |
| spellingShingle | Aves de Corral Pollo Parásitos Proteínas Enfoque Una salud Poultry Chickens Parasites Eimeria Proteins Coccidiosis One Health Approach Britez, Jesica Daiana Rodriguez, Anabel Elisa Di Ciaccio, Lucia Soledad Marugán-Hernandez, Virginia Tomazic, Mariela Luján What Do We Know about Surface Proteins of Chicken Parasites Eimeria? |
| title | What Do We Know about Surface Proteins of Chicken Parasites Eimeria? |
| title_full | What Do We Know about Surface Proteins of Chicken Parasites Eimeria? |
| title_fullStr | What Do We Know about Surface Proteins of Chicken Parasites Eimeria? |
| title_full_unstemmed | What Do We Know about Surface Proteins of Chicken Parasites Eimeria? |
| title_short | What Do We Know about Surface Proteins of Chicken Parasites Eimeria? |
| title_sort | what do we know about surface proteins of chicken parasites eimeria |
| topic | Aves de Corral Pollo Parásitos Proteínas Enfoque Una salud Poultry Chickens Parasites Eimeria Proteins Coccidiosis One Health Approach |
| url | http://hdl.handle.net/20.500.12123/14702 https://www.mdpi.com/2075-1729/13/6/1295 https://doi.org/10.3390/life13061295 |
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