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Alfalfa dwarf cytorhabdovirus P protein is a local and systemic RNA silencing supressor which inhibis program med RISC activity and prevents transitive amplification of RNA silencing

Plants employ RNA silencing as an innate defense mechanism against viruses. As a counter-defense, plant viruses have evolved to express RNA silencing suppressor proteins (RSS), which target one or more steps of the silencing pathway. In this study, we show that the phosphoprotein (P) encoded by th...

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Main Authors: Bejerman, Nicolas Esteban, Mann, Krin S., Dietzgen, Ralf Georg
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: 2017
Subjects:
Enfermedades de las Plantas
Medicago Sativa
Virus de las Plantas
Secuencia de ARN
Plant Diseases
Plant Viruses
RNA Sequence
RNA Viruses
Alfalfa
Online Access:http://hdl.handle.net/20.500.12123/1253
http://www.sciencedirect.com/science/article/pii/S0168170216303987?via%3Dihub
https://doi.org/10.1016/j.virusres.2016.08.008
Summary:Plants employ RNA silencing as an innate defense mechanism against viruses. As a counter-defense, plant viruses have evolved to express RNA silencing suppressor proteins (RSS), which target one or more steps of the silencing pathway. In this study, we show that the phosphoprotein (P) encoded by the negativesense RNA virus alfalfa dwarf virus (ADV), a species of the genus Cytorhabdovirus, family Rhabdoviridae, is a suppressor of RNA silencing. ADV P has a relatively weak local RSS activity, and does not prevent siRNA accumulation.

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