Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation

The effect of seasonality on Argentine propolis collected during one year on its phenolic and flavonoid content and on the growth of Gram-positive and Gram-negative antibiotic resistant bacteria and Candida species was evaluated. Extracts of propolis samples collected in the summer and spring showed...

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Autores principales: Isla, María Inés, Dantur, Yanina, Salas, Ana Lilia, Danert, Fátima Carolina, Zampini, Iris Catiana, Arias, Myriam, Ordóñez, Roxana Mabel, Maldonado, Luis Maria, Bedascarrasbure, Enrique Luciano, Nieva Moreno, María Inés
Formato: Artículo
Lenguaje:Inglés
Publicado: Sage Publishing 2022
Materias:
Acceso en línea:http://hdl.handle.net/20.500.12123/12344
https://journals.sagepub.com/doi/abs/10.1177/1934578X1200701015
https://doi.org/10.1177/1934578X1200701015
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author Isla, María Inés
Dantur, Yanina
Salas, Ana Lilia
Danert, Fátima Carolina
Zampini, Iris Catiana
Arias, Myriam
Ordóñez, Roxana Mabel
Maldonado, Luis Maria
Bedascarrasbure, Enrique Luciano
Nieva Moreno, María Inés
author_browse Arias, Myriam
Bedascarrasbure, Enrique Luciano
Danert, Fátima Carolina
Dantur, Yanina
Isla, María Inés
Maldonado, Luis Maria
Nieva Moreno, María Inés
Ordóñez, Roxana Mabel
Salas, Ana Lilia
Zampini, Iris Catiana
author_facet Isla, María Inés
Dantur, Yanina
Salas, Ana Lilia
Danert, Fátima Carolina
Zampini, Iris Catiana
Arias, Myriam
Ordóñez, Roxana Mabel
Maldonado, Luis Maria
Bedascarrasbure, Enrique Luciano
Nieva Moreno, María Inés
author_sort Isla, María Inés
collection INTA Digital
description The effect of seasonality on Argentine propolis collected during one year on its phenolic and flavonoid content and on the growth of Gram-positive and Gram-negative antibiotic resistant bacteria and Candida species was evaluated. Extracts of propolis samples collected in the summer and spring showed higher phenolic and flavonoid contents than the samples collected in other seasons (5.86 to 6.06 mg GAE/mL and 3.77 to 4.23 mg QE/mL, respectively). The propolis collected in summer and autumn showed higher antibacterial activity (30 μg/mL) than the other samples (MIC values between 30 and 120 μg/mL). No antibacterial activity was detected against Gram-negative bacteria. Also, these extracts were able to inhibit the development of five Candida species, with MFC values of 15-120 μg/mL. Pharmaceutical formulations containing the more active propolis extract were prepared. The hydrogel of acrylic acid polymer containing summer propolis extract as an antimicrobial agent showed microbiological, physical and functional stability during storage for 180 days. The pharmaceutical preparation, as well as the propolis extracts, was active against Candida sp. and antibiotic-multi-resistant Gram-positive bacteria. These results reveal that propolis samples collected by scraping in four seasons, especially in summer in Calingasta, San Juan, Argentina, can be used to obtain tinctures and hydrogels with antibacterial and antimycotic potential for topical use.
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spelling INTA123442022-07-18T14:55:32Z Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation Isla, María Inés Dantur, Yanina Salas, Ana Lilia Danert, Fátima Carolina Zampini, Iris Catiana Arias, Myriam Ordóñez, Roxana Mabel Maldonado, Luis Maria Bedascarrasbure, Enrique Luciano Nieva Moreno, María Inés Propóleos Estacionalidad Composición Quimica Propiedades Antimicrobianas Propiedades Antimicosicas Argentina Propolis Seasonality Chemical Composition Antimicrobial Properties Antifungal Properties Candida Propiedades Antibacteriales Antibacterial Properties The effect of seasonality on Argentine propolis collected during one year on its phenolic and flavonoid content and on the growth of Gram-positive and Gram-negative antibiotic resistant bacteria and Candida species was evaluated. Extracts of propolis samples collected in the summer and spring showed higher phenolic and flavonoid contents than the samples collected in other seasons (5.86 to 6.06 mg GAE/mL and 3.77 to 4.23 mg QE/mL, respectively). The propolis collected in summer and autumn showed higher antibacterial activity (30 μg/mL) than the other samples (MIC values between 30 and 120 μg/mL). No antibacterial activity was detected against Gram-negative bacteria. Also, these extracts were able to inhibit the development of five Candida species, with MFC values of 15-120 μg/mL. Pharmaceutical formulations containing the more active propolis extract were prepared. The hydrogel of acrylic acid polymer containing summer propolis extract as an antimicrobial agent showed microbiological, physical and functional stability during storage for 180 days. The pharmaceutical preparation, as well as the propolis extracts, was active against Candida sp. and antibiotic-multi-resistant Gram-positive bacteria. These results reveal that propolis samples collected by scraping in four seasons, especially in summer in Calingasta, San Juan, Argentina, can be used to obtain tinctures and hydrogels with antibacterial and antimycotic potential for topical use. EEA Famaillá Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina Fil: Isla, Maria Ines. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Isla, Maria Ines. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina Fil: Dantur, Yanina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Salas, Ana Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina Fil: Danert, Fátima C. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Química del Noroeste; Argentina Fil: Danert, Fátima Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Química del Noroeste; Argentina Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Arias, Myriam. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Fil: Ordóñez, Roxana Mabel. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fil: Ordóñez, Roxana Mabel. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Maldonado, Luis Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Bedascarrasbure, Enrique Luciano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Nieva Moreno, María Inés. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina 2022-07-18T14:52:20Z 2022-07-18T14:52:20Z 2012-10 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12344 https://journals.sagepub.com/doi/abs/10.1177/1934578X1200701015 1934-578X 1555-9475 https://doi.org/10.1177/1934578X1200701015 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Argentina .......... (nation) (World, South America) 7006477 Sage Publishing Natural Product Communications 7 (10) : 1315-1318 (October 2012)
spellingShingle Propóleos
Estacionalidad
Composición Quimica
Propiedades Antimicrobianas
Propiedades Antimicosicas
Argentina
Propolis
Seasonality
Chemical Composition
Antimicrobial Properties
Antifungal Properties
Candida
Propiedades Antibacteriales
Antibacterial Properties
Isla, María Inés
Dantur, Yanina
Salas, Ana Lilia
Danert, Fátima Carolina
Zampini, Iris Catiana
Arias, Myriam
Ordóñez, Roxana Mabel
Maldonado, Luis Maria
Bedascarrasbure, Enrique Luciano
Nieva Moreno, María Inés
Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation
title Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation
title_full Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation
title_fullStr Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation
title_full_unstemmed Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation
title_short Effect of Seasonality on Chemical Composition and Antibacterial and Anticandida Activities of Argentine Propolis. Design of a Topical Formulation
title_sort effect of seasonality on chemical composition and antibacterial and anticandida activities of argentine propolis design of a topical formulation
topic Propóleos
Estacionalidad
Composición Quimica
Propiedades Antimicrobianas
Propiedades Antimicosicas
Argentina
Propolis
Seasonality
Chemical Composition
Antimicrobial Properties
Antifungal Properties
Candida
Propiedades Antibacteriales
Antibacterial Properties
url http://hdl.handle.net/20.500.12123/12344
https://journals.sagepub.com/doi/abs/10.1177/1934578X1200701015
https://doi.org/10.1177/1934578X1200701015
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