Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Background: Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the inherent biophysical traits presented by an individual antigen of interest. N...

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Bibliographic Details

Main Authors:	Dalvie, Neil C., Brady, Joseph R., Crowell, Laura E., Tracey, Mary Kate, Biedermann, Andrew M., Kaur, Kawaljit, Hickey, John M., Kristensen II, D. Lee, Bonnyman, Alexandra D., Rodriguez-Aponte, Sergio A., Whittaker, Charles A., Bok, Marina, Vega, Celina Guadalupe, Mukhopadhyay, Tarit K., Joshi, Sangeeta B., Volkin, David B., Parreño, Gladys, Love, Kerry R., Love, J. Christopher
Format:	info:ar-repo/semantics/artículo
Language:	Inglés
Published:	BMC 2021
Subjects:	Vacuna Antígenos Genética Molecular Pichia pastoris Vaccines Rotavirus Antigens Molecular Genetics
Online Access:	http://hdl.handle.net/20.500.12123/10760 https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01583-6 https://doi.org/10.1186/s12934-021-01583-6