Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cat...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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2017
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/1053 https://jidc.org/index.php/journal/article/view/27580338/1568 https://doi.org/10.3855/jidc.7721 |
| _version_ | 1855482809593888768 |
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| author | Garcia, Elizabeth Andrea Bianco, María Veronica Blanco, Federico Carlos Bigi, Fabiana |
| author_browse | Bianco, María Veronica Bigi, Fabiana Blanco, Federico Carlos Garcia, Elizabeth Andrea |
| author_facet | Garcia, Elizabeth Andrea Bianco, María Veronica Blanco, Federico Carlos Bigi, Fabiana |
| author_sort | Garcia, Elizabeth Andrea |
| collection | INTA Digital |
| description | Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014).. |
| format | Artículo |
| id | INTA1053 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| record_format | dspace |
| spelling | INTA10532017-12-18T14:47:29Z Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis Garcia, Elizabeth Andrea Bianco, María Veronica Blanco, Federico Carlos Bigi, Fabiana Enfermedades de los Animales Mycobacterium Bovis Tuberculosis Infección por Mycobacterium Bovis Animal Diseases Mycobacterium Bovis Infections Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014).. Inst. de Biotecnología Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Bianco, María Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; Argentina Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina 2017-08-28T13:59:35Z 2017-08-28T13:59:35Z 2016 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/1053 https://jidc.org/index.php/journal/article/view/27580338/1568 García E, Bianco M, Blanco F, Bigi F (2016) Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis. The Journal Of Infection In Developing Countries 10 (08): 892-894. https://doi.org/10.3855/jidc.7721 2036-6590 (Print) 1972-2680 (Online) https://doi.org/10.3855/jidc.7721 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Journal Of Infection In Developing Countries 10 (8): 892-894 (August 2016) |
| spellingShingle | Enfermedades de los Animales Mycobacterium Bovis Tuberculosis Infección por Mycobacterium Bovis Animal Diseases Mycobacterium Bovis Infections Garcia, Elizabeth Andrea Bianco, María Veronica Blanco, Federico Carlos Bigi, Fabiana Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis |
| title | Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis |
| title_full | Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis |
| title_fullStr | Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis |
| title_full_unstemmed | Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis |
| title_short | Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis |
| title_sort | mycobacterium bovis deleted in mce2 and phop loci protects c57bl 6 mice against tuberculosis |
| topic | Enfermedades de los Animales Mycobacterium Bovis Tuberculosis Infección por Mycobacterium Bovis Animal Diseases Mycobacterium Bovis Infections |
| url | http://hdl.handle.net/20.500.12123/1053 https://jidc.org/index.php/journal/article/view/27580338/1568 https://doi.org/10.3855/jidc.7721 |
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