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Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis

Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cat...

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Main Authors: Garcia, Elizabeth Andrea, Bianco, Marí­a Veronica, Blanco, Federico Carlos, Bigi, Fabiana
Format: info:eu-repo/semantics/article
Language:Inglés
Published: 2017
Subjects:
Enfermedades de los Animales
Mycobacterium Bovis
Tuberculosis
Infección por Mycobacterium Bovis
Animal Diseases
Mycobacterium Bovis Infections
Online Access:http://hdl.handle.net/20.500.12123/1053
https://jidc.org/index.php/journal/article/view/27580338/1568
https://doi.org/10.3855/jidc.7721
Summary:Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014)..

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