Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Oxford university press
2017
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/1007 https://academic.oup.com/mbe/article/34/7/1722/3091105 https://doi.org/10.1093/molbev/msx114 |
| _version_ | 1855482802344034304 |
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| author | Demars, Julie Cano, Ema Margarita Drouilhet, Laurence Plisson-Petit, Florence Bardou, Philippe Fabre, Stéphane Servin, Bertrand Sarry, Julien Woloszyn, Florent Mulsant, Philippe Foulquier, Didier Carriere, Fabien Aletru, Mathias Rodde, Nathalie Cauet, Stéphane Bouchez, Olivier Pirson, Maarten Tosser-Klopp, Gwenola Allain, Daniel |
| author_browse | Aletru, Mathias Allain, Daniel Bardou, Philippe Bouchez, Olivier Cano, Ema Margarita Carriere, Fabien Cauet, Stéphane Demars, Julie Drouilhet, Laurence Fabre, Stéphane Foulquier, Didier Mulsant, Philippe Pirson, Maarten Plisson-Petit, Florence Rodde, Nathalie Sarry, Julien Servin, Bertrand Tosser-Klopp, Gwenola Woloszyn, Florent |
| author_facet | Demars, Julie Cano, Ema Margarita Drouilhet, Laurence Plisson-Petit, Florence Bardou, Philippe Fabre, Stéphane Servin, Bertrand Sarry, Julien Woloszyn, Florent Mulsant, Philippe Foulquier, Didier Carriere, Fabien Aletru, Mathias Rodde, Nathalie Cauet, Stéphane Bouchez, Olivier Pirson, Maarten Tosser-Klopp, Gwenola Allain, Daniel |
| author_sort | Demars, Julie |
| collection | INTA Digital |
| description | The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation. |
| format | Artículo |
| id | INTA1007 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Oxford university press |
| publisherStr | Oxford university press |
| record_format | dspace |
| spelling | INTA10072018-01-08T13:11:20Z Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep Demars, Julie Cano, Ema Margarita Drouilhet, Laurence Plisson-Petit, Florence Bardou, Philippe Fabre, Stéphane Servin, Bertrand Sarry, Julien Woloszyn, Florent Mulsant, Philippe Foulquier, Didier Carriere, Fabien Aletru, Mathias Rodde, Nathalie Cauet, Stéphane Bouchez, Olivier Pirson, Maarten Tosser-Klopp, Gwenola Allain, Daniel Genética Ovinos Mutación Genetics Sheep Mutation The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation. Instituto de Genética Fil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Foulquier, Didier. Institut National de la Recherche Agronomique; Francia Fil: Carriere, Fabien. Institut National de la Recherche Agronomique; Francia Fil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Rodde, Nathalie. Institut National de la Recherche Agronomique; Francia Fil: Cauet, Stéphane. Institut National de la Recherche Agronomique; Francia Fil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia 2017-08-22T17:11:50Z 2017-08-22T17:11:50Z 2017-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/1007 https://academic.oup.com/mbe/article/34/7/1722/3091105 1537-1719 https://doi.org/10.1093/molbev/msx114 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Oxford university press Molecular Biology and Evolution 34 (7) : 1722-1729 (July 2017) |
| spellingShingle | Genética Ovinos Mutación Genetics Sheep Mutation Demars, Julie Cano, Ema Margarita Drouilhet, Laurence Plisson-Petit, Florence Bardou, Philippe Fabre, Stéphane Servin, Bertrand Sarry, Julien Woloszyn, Florent Mulsant, Philippe Foulquier, Didier Carriere, Fabien Aletru, Mathias Rodde, Nathalie Cauet, Stéphane Bouchez, Olivier Pirson, Maarten Tosser-Klopp, Gwenola Allain, Daniel Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
| title | Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
| title_full | Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
| title_fullStr | Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
| title_full_unstemmed | Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
| title_short | Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
| title_sort | genome wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
| topic | Genética Ovinos Mutación Genetics Sheep Mutation |
| url | http://hdl.handle.net/20.500.12123/1007 https://academic.oup.com/mbe/article/34/7/1722/3091105 https://doi.org/10.1093/molbev/msx114 |
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