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Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep

The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a...

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Autores principales: Demars, Julie, Cano, Ema Margarita, Drouilhet, Laurence, Plisson-Petit, Florence, Bardou, Philippe, Fabre, Stéphane, Servin, Bertrand, Sarry, Julien, Woloszyn, Florent, Mulsant, Philippe, Foulquier, Didier, Carriere, Fabien, Aletru, Mathias, Rodde, Nathalie, Cauet, Stéphane, Bouchez, Olivier, Pirson, Maarten, Tosser-Klopp, Gwenola, Allain, Daniel
Formato: info:ar-repo/semantics/artículo
Lenguaje:Inglés
Publicado: Oxford university press 2017
Materias:
Genética
Ovinos
Mutación
Genetics
Sheep
Mutation
Acceso en línea:http://hdl.handle.net/20.500.12123/1007
https://academic.oup.com/mbe/article/34/7/1722/3091105
https://doi.org/10.1093/molbev/msx114
Sumario:The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.

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