Rapid method for the assessment of trypanocidal drug resistance in the field
Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalence o...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Conference Paper |
| Language: | Inglés |
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International Society for Veterinary Epidemiology and Economics
2000
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/51007 |
| _version_ | 1855520409034686464 |
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| author | Eisler, M.C. McDermott, John J. Mdachi, R. Murilla, G. Sinyangwe, L. Mubanga, J. Machila, N. Mbwambo, H. Coleman, P.G. Clausen, Peter-Henning Bauer, B. Sidibe, I. Geerts, S. Holmes, P.H. Peregrine, A.S. |
| author_browse | Bauer, B. Clausen, Peter-Henning Coleman, P.G. Eisler, M.C. Geerts, S. Holmes, P.H. Machila, N. Mbwambo, H. McDermott, John J. Mdachi, R. Mubanga, J. Murilla, G. Peregrine, A.S. Sidibe, I. Sinyangwe, L. |
| author_facet | Eisler, M.C. McDermott, John J. Mdachi, R. Murilla, G. Sinyangwe, L. Mubanga, J. Machila, N. Mbwambo, H. Coleman, P.G. Clausen, Peter-Henning Bauer, B. Sidibe, I. Geerts, S. Holmes, P.H. Peregrine, A.S. |
| author_sort | Eisler, M.C. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalence of trypanocidal drug resistance in the area. Standard laboratory methods to characterise drug resistance in trypanosomes, both in vivo and in vitro, are expensive and time-consuming. In addition, the results of assays in rodents may only approximate the drug resistance status of individual trypanosome populations in cattle. To overcome these constraints, we have developed and applied methods for the assessment of trypanosomosis risk and the level and prevalence of resistance to isometamidium (ISMM), the main prophylactic/curative trypanocide used in sub-Saharan Africa, utilising cattle populations under natural challenge in the field Survival analysis of time to first detection of a trypanosome infection in cattle following a prophylactic ISMM treatment has previously been used in the comparison of conventional intramuscular treatment with treatment using sustained release devices. In this work we describe use of survival analysis in the assessment of trypanocidal drug resistance in cattle under natural tsetse challenge. |
| format | Conference Paper |
| id | CGSpace51007 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2000 |
| publishDateRange | 2000 |
| publishDateSort | 2000 |
| publisher | International Society for Veterinary Epidemiology and Economics |
| publisherStr | International Society for Veterinary Epidemiology and Economics |
| record_format | dspace |
| spelling | CGSpace510072024-03-06T10:16:43Z Rapid method for the assessment of trypanocidal drug resistance in the field Eisler, M.C. McDermott, John J. Mdachi, R. Murilla, G. Sinyangwe, L. Mubanga, J. Machila, N. Mbwambo, H. Coleman, P.G. Clausen, Peter-Henning Bauer, B. Sidibe, I. Geerts, S. Holmes, P.H. Peregrine, A.S. trypanosomiasis drug resistance methods drug treatment Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalence of trypanocidal drug resistance in the area. Standard laboratory methods to characterise drug resistance in trypanosomes, both in vivo and in vitro, are expensive and time-consuming. In addition, the results of assays in rodents may only approximate the drug resistance status of individual trypanosome populations in cattle. To overcome these constraints, we have developed and applied methods for the assessment of trypanosomosis risk and the level and prevalence of resistance to isometamidium (ISMM), the main prophylactic/curative trypanocide used in sub-Saharan Africa, utilising cattle populations under natural challenge in the field Survival analysis of time to first detection of a trypanosome infection in cattle following a prophylactic ISMM treatment has previously been used in the comparison of conventional intramuscular treatment with treatment using sustained release devices. In this work we describe use of survival analysis in the assessment of trypanocidal drug resistance in cattle under natural tsetse challenge. 2000 2014-10-31T06:21:58Z 2014-10-31T06:21:58Z Conference Paper https://hdl.handle.net/10568/51007 en Limited Access International Society for Veterinary Epidemiology and Economics |
| spellingShingle | trypanosomiasis drug resistance methods drug treatment Eisler, M.C. McDermott, John J. Mdachi, R. Murilla, G. Sinyangwe, L. Mubanga, J. Machila, N. Mbwambo, H. Coleman, P.G. Clausen, Peter-Henning Bauer, B. Sidibe, I. Geerts, S. Holmes, P.H. Peregrine, A.S. Rapid method for the assessment of trypanocidal drug resistance in the field |
| title | Rapid method for the assessment of trypanocidal drug resistance in the field |
| title_full | Rapid method for the assessment of trypanocidal drug resistance in the field |
| title_fullStr | Rapid method for the assessment of trypanocidal drug resistance in the field |
| title_full_unstemmed | Rapid method for the assessment of trypanocidal drug resistance in the field |
| title_short | Rapid method for the assessment of trypanocidal drug resistance in the field |
| title_sort | rapid method for the assessment of trypanocidal drug resistance in the field |
| topic | trypanosomiasis drug resistance methods drug treatment |
| url | https://hdl.handle.net/10568/51007 |
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