Characterization of the novel Trypanosoma brucei inosine 5′-monophosphate dehydrogenase
There is an alarming rate of human African trypanosomiasis recrudescence in many parts of sub-Saharan Africa. Yet, the disease has no successful chemotherapy. Trypanosoma lacks the enzymatic machinery for the de novo synthesis of purine nucleotides, and is critically dependent on salvage mechanisms....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Cambridge University Press
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/41905 |
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