Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all ap...
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
American Association for the Advancement of Science
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/33167 |
| _version_ | 1855514467723378688 |
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| author | Gardner, M.J. Bishop, Richard P. Shah, Tushaar Villiers, Etienne P. de Carlton, J.M. Hall, N. Ren, Q. Paulsen, I.T. Pain, A. Berriman, M. Wilson, R.J.M. Sato, S. Ralph, S.A. Mann, D.J. Xiong, Z. Shallom, S.J. Weidman, J. Jiang, L. Lynn,, J. Weaver, B. Shoaibi, A. Domingo, A.R. Wasawo, D. Crabtree, J. Wortman, Jennifer R. Haas, B. Angiuoli, S.V. Creasy, T.H. Lu, C. Suh, B. Silva, Joana C. Utterback, T.R. Feldblyum, T.V. Pertea, M. Allen, J. Nierman, W.C. Taracha, E.L.N. Salzberg, S.L. White, O.R. Fitzhugh, H.A. Morzaria, S.P. Venter, J. Craig Fraser, C.M. Nene, Vishvanath M. |
| author_browse | Allen, J. Angiuoli, S.V. Berriman, M. Bishop, Richard P. Carlton, J.M. Crabtree, J. Creasy, T.H. Domingo, A.R. Feldblyum, T.V. Fitzhugh, H.A. Fraser, C.M. Gardner, M.J. Haas, B. Hall, N. Jiang, L. Lu, C. Lynn,, J. Mann, D.J. Morzaria, S.P. Nene, Vishvanath M. Nierman, W.C. Pain, A. Paulsen, I.T. Pertea, M. Ralph, S.A. Ren, Q. Salzberg, S.L. Sato, S. Shah, Tushaar Shallom, S.J. Shoaibi, A. Silva, Joana C. Suh, B. Taracha, E.L.N. Utterback, T.R. Venter, J. Craig Villiers, Etienne P. de Wasawo, D. Weaver, B. Weidman, J. White, O.R. Wilson, R.J.M. Wortman, Jennifer R. Xiong, Z. |
| author_facet | Gardner, M.J. Bishop, Richard P. Shah, Tushaar Villiers, Etienne P. de Carlton, J.M. Hall, N. Ren, Q. Paulsen, I.T. Pain, A. Berriman, M. Wilson, R.J.M. Sato, S. Ralph, S.A. Mann, D.J. Xiong, Z. Shallom, S.J. Weidman, J. Jiang, L. Lynn,, J. Weaver, B. Shoaibi, A. Domingo, A.R. Wasawo, D. Crabtree, J. Wortman, Jennifer R. Haas, B. Angiuoli, S.V. Creasy, T.H. Lu, C. Suh, B. Silva, Joana C. Utterback, T.R. Feldblyum, T.V. Pertea, M. Allen, J. Nierman, W.C. Taracha, E.L.N. Salzberg, S.L. White, O.R. Fitzhugh, H.A. Morzaria, S.P. Venter, J. Craig Fraser, C.M. Nene, Vishvanath M. |
| author_sort | Gardner, M.J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated. |
| format | Journal Article |
| id | CGSpace33167 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | American Association for the Advancement of Science |
| publisherStr | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | CGSpace331672024-03-03T19:19:11Z Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes Gardner, M.J. Bishop, Richard P. Shah, Tushaar Villiers, Etienne P. de Carlton, J.M. Hall, N. Ren, Q. Paulsen, I.T. Pain, A. Berriman, M. Wilson, R.J.M. Sato, S. Ralph, S.A. Mann, D.J. Xiong, Z. Shallom, S.J. Weidman, J. Jiang, L. Lynn,, J. Weaver, B. Shoaibi, A. Domingo, A.R. Wasawo, D. Crabtree, J. Wortman, Jennifer R. Haas, B. Angiuoli, S.V. Creasy, T.H. Lu, C. Suh, B. Silva, Joana C. Utterback, T.R. Feldblyum, T.V. Pertea, M. Allen, J. Nierman, W.C. Taracha, E.L.N. Salzberg, S.L. White, O.R. Fitzhugh, H.A. Morzaria, S.P. Venter, J. Craig Fraser, C.M. Nene, Vishvanath M. theileria parva bovinae genomes nucleotide sequence lymphocytes cell mediated immunity pathogens small farms plasmodium falciparum chromosomes dna We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated. 2005-07 2013-07-03T05:26:09Z 2013-07-03T05:26:09Z Journal Article https://hdl.handle.net/10568/33167 en Open Access American Association for the Advancement of Science Science;309(5731): 134-137 |
| spellingShingle | theileria parva bovinae genomes nucleotide sequence lymphocytes cell mediated immunity pathogens small farms plasmodium falciparum chromosomes dna Gardner, M.J. Bishop, Richard P. Shah, Tushaar Villiers, Etienne P. de Carlton, J.M. Hall, N. Ren, Q. Paulsen, I.T. Pain, A. Berriman, M. Wilson, R.J.M. Sato, S. Ralph, S.A. Mann, D.J. Xiong, Z. Shallom, S.J. Weidman, J. Jiang, L. Lynn,, J. Weaver, B. Shoaibi, A. Domingo, A.R. Wasawo, D. Crabtree, J. Wortman, Jennifer R. Haas, B. Angiuoli, S.V. Creasy, T.H. Lu, C. Suh, B. Silva, Joana C. Utterback, T.R. Feldblyum, T.V. Pertea, M. Allen, J. Nierman, W.C. Taracha, E.L.N. Salzberg, S.L. White, O.R. Fitzhugh, H.A. Morzaria, S.P. Venter, J. Craig Fraser, C.M. Nene, Vishvanath M. Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes |
| title | Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes |
| title_full | Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes |
| title_fullStr | Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes |
| title_full_unstemmed | Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes |
| title_short | Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes |
| title_sort | genome sequence of theileria parva a bovine pathogen that transforms lymphocytes |
| topic | theileria parva bovinae genomes nucleotide sequence lymphocytes cell mediated immunity pathogens small farms plasmodium falciparum chromosomes dna |
| url | https://hdl.handle.net/10568/33167 |
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