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Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all ap...

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Autores principales: Gardner, M.J., Bishop, Richard P., Shah, Tushaar, Villiers, Etienne P. de, Carlton, J.M., Hall, N., Ren, Q., Paulsen, I.T., Pain, A., Berriman, M., Wilson, R.J.M., Sato, S., Ralph, S.A., Mann, D.J., Xiong, Z., Shallom, S.J., Weidman, J., Jiang, L., Lynn,, J., Weaver, B., Shoaibi, A., Domingo, A.R., Wasawo, D., Crabtree, J., Wortman, Jennifer R., Haas, B., Angiuoli, S.V., Creasy, T.H., Lu, C., Suh, B., Silva, Joana C., Utterback, T.R., Feldblyum, T.V., Pertea, M., Allen, J., Nierman, W.C., Taracha, E.L.N., Salzberg, S.L., White, O.R., Fitzhugh, H.A., Morzaria, S.P., Venter, J. Craig, Fraser, C.M., Nene, Vishvanath M.
Formato: Journal Article
Lenguaje:Inglés
Publicado: American Association for the Advancement of Science 2005
Materias:
theileria parva
bovinae
genomes
nucleotide sequence
lymphocytes
cell mediated immunity
pathogens
small farms
plasmodium falciparum
chromosomes
dna
Acceso en línea:https://hdl.handle.net/10568/33167
Sumario:We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.

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