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Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva

Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigen...

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Main Authors: Hall, R., Boulter, N.R., Brown, C.G.D., Wilkie, G., Kirvar, E., Nene, Vishvanath M., Musoke, A.J., Glass, E.J., Morzaria, S.P.
Format: Journal Article
Language:Inglés
Published: Wiley 2000
Subjects:
theileria parva
theleria annulata
antigens
sporozoa
vaccines
east coast fever
calves
immunization
Online Access:https://hdl.handle.net/10568/33093
Summary:Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.

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