Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva
Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigen...
| Autores principales: | , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2000
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/33093 |
| _version_ | 1855527150662189056 |
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| author | Hall, R. Boulter, N.R. Brown, C.G.D. Wilkie, G. Kirvar, E. Nene, Vishvanath M. Musoke, A.J. Glass, E.J. Morzaria, S.P. |
| author_browse | Boulter, N.R. Brown, C.G.D. Glass, E.J. Hall, R. Kirvar, E. Morzaria, S.P. Musoke, A.J. Nene, Vishvanath M. Wilkie, G. |
| author_facet | Hall, R. Boulter, N.R. Brown, C.G.D. Wilkie, G. Kirvar, E. Nene, Vishvanath M. Musoke, A.J. Glass, E.J. Morzaria, S.P. |
| author_sort | Hall, R. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future. |
| format | Journal Article |
| id | CGSpace33093 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2000 |
| publishDateRange | 2000 |
| publishDateSort | 2000 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace330932024-01-17T12:58:34Z Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva Hall, R. Boulter, N.R. Brown, C.G.D. Wilkie, G. Kirvar, E. Nene, Vishvanath M. Musoke, A.J. Glass, E.J. Morzaria, S.P. theileria parva theleria annulata antigens sporozoa vaccines east coast fever calves immunization Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future. 2000-05 2013-07-03T05:26:03Z 2013-07-03T05:26:03Z Journal Article https://hdl.handle.net/10568/33093 en Limited Access Wiley Parasite Immunology;22(5): 223-230 |
| spellingShingle | theileria parva theleria annulata antigens sporozoa vaccines east coast fever calves immunization Hall, R. Boulter, N.R. Brown, C.G.D. Wilkie, G. Kirvar, E. Nene, Vishvanath M. Musoke, A.J. Glass, E.J. Morzaria, S.P. Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva |
| title | Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva |
| title_full | Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva |
| title_fullStr | Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva |
| title_full_unstemmed | Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva |
| title_short | Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva |
| title_sort | reciprocal cross protection induced by sporozoite antigens spag 1 from theileria annulata and p67 from theileria parva |
| topic | theileria parva theleria annulata antigens sporozoa vaccines east coast fever calves immunization |
| url | https://hdl.handle.net/10568/33093 |
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