Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene
Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous subst...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
1999
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/30064 |
| _version_ | 1855522029204144128 |
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| author | Gelhaus, A. Hanotte, Olivier H. Horstmann, R.D. Teale, A.J. |
| author_browse | Gelhaus, A. Hanotte, Olivier H. Horstmann, R.D. Teale, A.J. |
| author_facet | Gelhaus, A. Hanotte, Olivier H. Horstmann, R.D. Teale, A.J. |
| author_sort | Gelhaus, A. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous substitutions in the encoding gene (MANB). Primers for MANB were designed from a bovine sequence (Gen Bank accession number U97686) and amplified a 316-bp fragment comprising intron 2 and adjacent exonic sequences. This paper discusses PCR primers, PCR conditions and polymorphism detection; and allele frequencies, inheritance and chromosomal location. |
| format | Journal Article |
| id | CGSpace30064 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1999 |
| publishDateRange | 1999 |
| publishDateSort | 1999 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace300642024-05-01T08:16:37Z Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene Gelhaus, A. Hanotte, Olivier H. Horstmann, R.D. Teale, A.J. bovidae genes genetic maps lysozyme Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous substitutions in the encoding gene (MANB). Primers for MANB were designed from a bovine sequence (Gen Bank accession number U97686) and amplified a 316-bp fragment comprising intron 2 and adjacent exonic sequences. This paper discusses PCR primers, PCR conditions and polymorphism detection; and allele frequencies, inheritance and chromosomal location. 1999-06 2013-06-11T09:26:04Z 2013-06-11T09:26:04Z Journal Article https://hdl.handle.net/10568/30064 en Limited Access Wiley Animal Genetics;30: 227-228 |
| spellingShingle | bovidae genes genetic maps lysozyme Gelhaus, A. Hanotte, Olivier H. Horstmann, R.D. Teale, A.J. Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene |
| title | Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene |
| title_full | Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene |
| title_fullStr | Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene |
| title_full_unstemmed | Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene |
| title_short | Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene |
| title_sort | linkage mapping of the bovine lysosomal alphamannosidase manb gene |
| topic | bovidae genes genetic maps lysozyme |
| url | https://hdl.handle.net/10568/30064 |
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