Antigenic variation in Trypanosoma vivax. Isolation of a serodeme
Studies of antigenic variation inTrypanosoma vivaxhave been hindered by its low infectivity to laboratory hosts and difficulties in obtaining defined cloned populations. The recent isolation of mouse-infectiveT. vivaxhas partially overcome the first problem. We have developed a highly efficient clon...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Cambridge University Press
1984
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/29431 |
| Summary: | Studies of antigenic variation inTrypanosoma vivaxhave been hindered by its low infectivity to laboratory hosts and difficulties in obtaining defined cloned populations. The recent isolation of mouse-infectiveT. vivaxhas partially overcome the first problem. We have developed a highly efficient cloning technique which has been applied to the isolation of a collection of 71 clones, representing 31 distinct variable antigen types, of mouse-infectiveT. vivaxfrom Nigeria. This serodeme showed no cross-reaction with severalT. brucei-group serodemes, but some cross-reaction with naturally occurring KenyanT. vivax. |
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